AstraZeneca Exec Was Pressed To Lie About Seroquel Weight Gain

Well, this ought to be fun for AstraZeneca to explain in court. The BBC is reporting that a former UK AZ executive was pressed by AZ marketing execs to lie about weight gain issues with Seroquel in the late-1990s.

"John Blenkinsop, the company's former UK medical manager, claimed he was pressurised by the company's marketing arm to approve claims about the drug which he felt did not reflect the medical evidence.

"'The clinical studies at the time of the launch of Seroquel showed patients developed significant weight gain, significant both statistically and clinically,' he told the BBC's File on 4.

"'They [the marketing team] came at me with a number of potential claims all of which were trying to intimate that Seroquel was not associated with weight gain - the data pointed in the opposite direction,' added Mr Blenkinsop who was speaking publicly for the first time since he left the company in 2000.

"He said: 'I understood where they were coming from. I had some robust discussions and exposed them to the data but that didn't seem to stop them because they were desperate for a differential advantage over one of the competitor products and they didn't have one.

"'In the end I was put under quite a significant amount of pressure by the marketeers to sign off claims with regards to the lack of weight gain and I was unwilling to sign that off. The marketeers made it clear it could be career limiting for me," Mr Blenkinsop added.'"

Of course, this weight gain would have absolutely nothing to do with diabetes associated with the use of the drug, so there's no need for the public to know.