October 27, 2009

JAMA Study Finds Explosive Weight Gain In Kids On Antipsychotics

A study to be published in JAMA tomorrow finds staggering weight gain in kids given antipsychotics. According to the AP:

"Children on widely used psychiatric drugs can quickly gain an alarming amount of weight; many pack on nearly 20 pounds and become obese within just 11 weeks, a study found.

"'Sometimes this stuff just happens like an explosion. You can actually see them grow between appointments,' said Dr. Christopher Varley, a psychiatrist with Seattle Children's Hospital who called the study 'sobering.'

"Weight gain is a known possible side effect of the anti-psychotic drugs which are prescribed for bipolar disorder and schizophrenia, but also increasingly for autism, attention deficit disorders and other behavior problems. The new study in mostly older children and teens suggests they may be more vulnerable to weight gain than adults."

That is very rapid and very significant weight gain. The drugs involved were Risperdal, Seroquel, Zyprexa and Abilify. Since I've not seen the study, which involved 205 New York-area kids aged 4 to 17, I don't know what range of diagnoses kids were getting these drugs for, but it'll likely be the usual muddle of schizophrenia, pediatric bipolar disorder, autism, ADHD and so on.

If this study does not give pause to those who wish to medicate kids, then nothing will.

Posted by Philip Dawdy at October 27, 2009 11:51 AM
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Comments

The link between atypical antipsychotics and weight gain in adults has been known for some time. So this finding can't possibly come as any surprise. We know that kids react more strongly to some things than adults do, and this is a relatively young class of meds.

Bearing that in mind, I hope this finding doesn't cause any changes in prescribing practices; I hope that the doctors were keeping in mind the lack of existing data on these meds and were using extreme caution to begin with. I mean, my God, age 4?? I can only hope that prescribing an antipsychotic for a 4-year-old is an act of last resort.

(On a side note, the Zyprexa label says overdose can't hurt you too bad, much like with the SSRIs, so I have no explanation as to why I had to be placed on mechanical ventilation for a day after my overdose. But let's stay tuned for more findings!)

To clarify, I am super NOT anti psych med. I have seen firsthand how they can give people their lives back. They can be so helpful that if a person really needs the help, they can be worth the side effects, so why not go ahead and be honest about them, then? When people are not given all the information, they'll be more prone to do stuff like go off the meds on their own, and then they're out there flipping out with no medical help.

I do not believe in a drug conspiracy. I do believe that many (not all) psychiatrists have gigantic inflated egos that somehow work like funhouse mirrors to magically transform everybody from a human being into a constellation of symptoms.

Thanks for your website; it's fun for me when I don't feel like studying.

Posted by: Sarah at October 27, 2009 04:51 PM

By the way, I loved my Zyprexa weight gain. Anything that can put 15 pounds on my determinedly scrawny little body is some serious shit.

Posted by: Sarah at October 27, 2009 05:16 PM

Thank you Dr. Biederman.

Posted by: JC at October 27, 2009 07:41 PM

...so very sad.

Posted by: JJ at October 27, 2009 10:36 PM

I agree this is a big problem. I'm glad you post these findings - they are important for people to know.

Posted by: Meg at October 31, 2009 09:00 PM
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