September 03, 2009

More Possible Non-Disclosures For Depression In 3-Year-Olds Researcher

On Tuesday I wrote of a possible non-disclosure of pharma monies by Joan Luby, a Washington University psychiatry professor, in an August 2009 paper in the Archives of General Psychiatry. In that paper, which asserted that child as young as three can and do experience chronic depression, Luby appears to have failed to disclose monies she'd received with the last five years from AstraZeneca, Shire and Janssen/J&J.

Luby is interested in more than depression in preschoolers. She has also authored papers on "preschool bipolar disorder," written that anitpsychotics are a suitable treatment and ranks with Harvard child psychiatrists Joseph Biederman and Washington University's Barbara Geller as one of the prime proponents of the bipolar child paradigm--a controversial paradigm to say the least.

Now, it's apparent that she has similar possible disclosure problems with a paper on "Early Childhood Depression" in this month's American Journal of Psychiatry and with a 2003 paper in the Archives.

At the AJP paper's end, Luby only notes under disclosures that she receives royalties from a book. While the AJP does not specify any particular time window within which an author must disclose possible conflicts, it does require that authors note relevant conflicts. Seeing as Luby received monies from AstraZeneca, a company that's quite interested in its antipsychotic Seroquel being used for depression, in 2003 and 2004, it's baffling that she wouldn't list the AZ monies as well as monies from Janssen/J&J, another company interested in seeing its antipsychotic, Risperdal, used for depression.

I've brought this matter to the attention of the AJP's editor and the press office at the American Psychiatric Association, which publishes the journal. In addition, I've contacted Luby, asking her to account for this apparent discrepancy. None of the parties replied to my requests for comment.

Luby's paper examines treatment considerations for preschoolers with depression, a controversial assertion even within psychiatry itself. To be fair, Luby isn't pushing meds for tots in the paper. She discusses psychotherapeutic approaches and states that:

"The use of antidepressant medications is not recommended as a first- or second-line treatment at this time."

All the same, as wild a claim as toddlers with depression sounds, Luby should be a lot more upfront about to what degree pharma companies may be biasing her assertions.

A December 2003 paper by Luby entitled "Alterations in Stress Cortisol Reactivity in Depressed Preschoolers Relative to Psychiatric and No-Disorder Comparison Groups" raises similar questions. Luby often cites this article in her subsequent work on depression in kiddos as establishing the mechanism of depression in their cases. In the paper, she asserts that she's detected hypothalamic-pituitary-adrenal (HPA) reactivity in depressed preschoolers. HPA reactivity is far from settled science in establishing a cause of depression.

In this paper, Luby discloses that she's gotten funding from the National Institute of Mental Health and the National Alliance for Research on Schizophrenia and Depression. NARSAD is a non-profit foundation. What Luby fails to disclose is that in 2003 she received monies from AstraZeneca. It's not clear if she was receiving monies from Shire and Janssen/J&J in 2003 or at any earlier date that would've triggered disclosure in the journal.

Nonetheless, it would stand to reason that she should've listed the AZ monies on her paper, especially since she was at the same time receiving federal research funding.

I've contacted Luby asking her to explain this apparent discrepancy. Luby has not responded to my request for comment.

So far, I've heard back from only the AMA's press office and only to the effect that the AGP's editor is out until next week. Stay tuned.

BTW, much credit to Jim Edwards at Bnet.com's Pharma Blog for this all started last week.

Posted by Philip Dawdy at September 3, 2009 12:03 AM
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Comments

I started writing about this and was starting research on possible conflict of interests with drug companies. I googled Luby and AstraZeneca, etc.

What brought my attn to Luby was the 3 yr old depression article, and consequently found her other papers.

Luby's work to dx these children uses a dog puppet and a 16 question paper that parents fill out. It sounded like complete bunk and smelled of a drug company funded researcher if I ever read one.

I had other things come up before I could keep persuing my thoughts...which have evolved in print here...kudos to you and Jim Edwards, all I can say is this is SO typical, even I, the mom who isn't a journalist knew something was up with Luby.

Predictable corruption, sure isn't what we want in our medication based psychiatric paradigm called "psychiatric care".

Great work, keep it going.

Posted by: Stephany at September 3, 2009 01:30 AM

Thank you Philip for this article and also to Stephany for the additional information. Learning that our doctors are teaching our 3-year-olds that they need anti-depressant medication disturbs me. It reminds me of a recent session I had (I am a therapist). A client shared that a former therapist had advised her to identify the name of the character within him who was depressed. She named him "Ted" and was then told by the therapist to ask "Ted" to go away. That seemed unbelievably trite to me. Depth and richness in life is discovered through having time and space to understand what our depressions are trying to tell us. Experience, reflection and understanding take time to unfold. It is interesting to see how the world's stage and cast of characters is getting smaller and smaller. Soon we will only have room for two characters, Good and Bad. Is this what we want to teach our children? That certain feelings and unfolding of experience are unacceptable? We seem to have less and less room for complexity.

Posted by: JJ at September 3, 2009 12:46 PM

@JJ...Soon we will only have room for two characters, Good and Bad...

Don't be so archaic. You mean the two characters, Health and Unhealth. Surely, you also don't believe in *gasp* the Soul? Any sane person knows that we are but the sum total of our brain's electro-chemical impulses.

/snark

Posted by: marlborojones at September 3, 2009 04:43 PM

...and have nothing to learn from the wisdom of old, eh snark?

Posted by: JJ at September 3, 2009 08:45 PM

@JJ Psychiatry seems to be one profession that can never learn from its prior experience. I guess a clear conscience really is a sign of a faulty memory.

Posted by: marlborojones at September 4, 2009 11:54 AM

"Psychiatry seems to be one profession that can never learn from its prior experience. I guess a clear conscience really is a sign of a faulty memory."

Who wrote that? I totally agree, especially after talking to an inpatient psychiatrist (actually after being talked down to by one)today.

Things will never change if people on the inside don't!

Posted by: Stephany at September 4, 2009 01:17 PM

Regarding Luby's comment that "The use of antidepressant medications is not recommended as a first- or second-line treatment at this time":

I'm glad she wrote that, and I'm glad you point it out. Unfortunately, I'm afraid that statement (if it's even noticed) is probably lost on most psychiatrists. Their thinking is probably more along the lines of, "well, the parents bought Junior a toy [first-line treatment] and that didn't work, then they invited other kids over to play with Junior [second-line treatment], and he still seems sad, so it must be time to start the meds!"

Posted by: SteveBMD at September 4, 2009 03:02 PM

Good to see depression is making a comeback again. The past few years depression had been absorbed under the classification of bipolar II/cyclothymia. I suppose the patents on abilify and seroquel are running out, and a new crop of branded ADs lies on the horizon. That is the only possible explanation for this increasing talk of "depression" which for the past 4 or 5 years seemed to have vanished.

I missed thinking of myself as depressed. I don't really like the whole "bipolar II" thing, it sorta pathologizes productivity and happiness which is at least annoying.

Posted by: noone at September 13, 2009 12:24 AM

This article seems to be trying to attribute some ulterior motive to research which, if one reads it, describes discoveries about early warning signs of a disease. How does that segue to the suggestion that the principal author or any of her associates are shills for some drug vendor?



You even recognize that the article, though focused on detection rather than treatment, happens to advise against the use of pharmaceuticals. So even if their research had led them to different conclusions, I'm puzzled as to why you would attempt to victimize what their resumes represent as honorable professionals. I would hope that pharma companies listen closely to Drs of various specialties but, unless they obtained their degrees from a matchbook, I seriously doubt their lifetime of learning can be subjugated for their nominal speaking fees.



I get skeptical too when I read the publications about the health benefits of red wine that are sponsored by vintners, and everyone can agree that direct funding, sponsorship or participation of vendors in research must be cited. But it is a needless and cynical imposition to suggest that every vendor who has ever hired a Dr belongs in a permanent section of their bibliography.



The saddest part of this attempt at character assassination is in some of the ensuing comments, where that faulty premise propagates into even more grotesque distortions, ("smelled of a drug company funded researcher if I ever read one", "our doctors are teaching our 3-year-olds that they need anti-depressant medication", ""her assertion elsewhere that antipsychotics are an awesome treatment for kids"), of the actual content. I personally find discussion and debate of research findings far healthier than reckless attacks on the integrity or motives of its authors.

Philip Dawdy responds: no character assassination here. note that i queried the person in question and she chose not to respond. also, what's at issue is whether she's in violation of the disclosure policy of the journals in question.

Posted by: fellow590 at September 29, 2009 06:22 PM
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