Furious Seasons

September 22, 2009

Fall Fundraiser, Inching Ahead

Another $45 came in yesterday from two people bringing the total raised so far to $2,674.49 from 54 people. That leaves $1,325.51 from 46 people to go to reach the overall goal of $4,000 from 100 people by the end of this coming Friday, which is this site's fourth anniversary. Thanks to all of you who've contributed so far.

I know a couple of contributions are headed my way by mail, so I'm not pushing the panic button yet. But it'd be great if some more contributions came in today. As usual, the PayPal button is on the right. If you prefer snail mail, send me an email and I'll send you my mailing address.

Thanks in advance for your support.

Posted by Philip Dawdy at September 22, 2009 12:05 AM

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Comments

Some of the major articles and studies that center on the effects of atypical antipsychotics on metabolic processes, are listed below. Studies on diabetes, two of them are also included, that could hold import on the maladies of the AAP induced medical conditions, particularly diabetes.

(1) "Acute Effects of Atypical Antipsychotics on Whole Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects."
Houseknecht et al.
(2) "Schizophrenia and adverse effects of its treatements on Mitochondrial Metabolism" Richard Fiddian Green BMJ.
(3) "Atypical Antipsychotics activate Hypothalamic AMPK" Elizabeth Adler.
(4) "The ROle of Vitamin D and Calcium in type 2 Diabetes. A systematic Review and Meta-Analysis. ANastassios G. Pittas.
(5) "Atypical Antipsychotics and Diabetes Mellitus: An Association." Israeli Study.
(6) "Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse. Evidence for the Involvement of Sympathetic Regulation." Yvette E. Savoy. Schizophrenia Bulletin August 14, 2008.
(7) "Atypical Antipsychotics Drugs Directly Impair Insulin Action in Adipocytes: Effects on Glucose Transport, Lipogenesis, and Antilipolysis." Vestri et al. Neuropsychopharmacology.
(8) Metabolic Dysregulation with Atypical Antipsychotics occurs in the Absence of Underlying Disease: a placebo - controlled study of olanzapine and risperidone in dogs." Diabetes 54:862-...Ader et al.
(9) "Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment." Minet-Ringuet et al.
(10) "John Fetzel : The Next Nobel Prize? Joint US - Canadian Research..."

Also February 2004 American Journal of Psychiatry artcile by Oliver D. Howes: his study on clozapine's impairment of glucose control without changes in insulin resistance. That article can be added to the above ten articles.
These are ten to eleven major studies over the past five years, generally, that hold significant information illustrating the various dimensions of AAP induced metabolic disturbances.

Posted by: Harry Horton at September 23, 2009 10:52 AM