August 27, 2009Women Commits Suicide By OD'ing On Celexa, EffexorRemember when the new generation anti-depressants came into the world in the late-80s and 1990s and one of their supposed advantages over older anti-depressants was that a patient couldn't use them to overdose and commit suicide a la Nick Drake, the great singer-songwriter? Well here's the sad, tragic case of Kimberly Hatch, a 40-year-old woman in New York who killed herself last year by OD'ing on anti-depressants. "The results of an autopsy and toxicological examination have determined the cause of death to be from respiratory suppression with pulmonary edema, secondary to a drug overdose, a release from the state police says. I've not heard of too many cases where newish anti-depressants were determined to be the cause of death by overdose. So much for anti-depressants being safe in this respect. Tragically so. Posted by Philip Dawdy at August 27, 2009 12:03 AM
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So sad. So heart-wrenchingly sad. Thoughts of love for her dear ones. Posted by: Sophie in the Moonlight at August 27, 2009 09:06 AMRumor has it this is how Jasmine You of Versailles committed suicide and died on August 9th. The organ failure made it inevitable. Posted by: No one at August 27, 2009 10:52 AMI don't take these cases "ruled as suicide" at face value. I've seen so many reports of people being prescribed cocktails of drugs that shouldn't be taken together and at higher doses then recommended on the labels. With doctor's not taking into account drug interactions and how they are illuminated from the body, etc.; I wouldn’t be surprised if the drugs were taken as prescribed and the woman wasn’t warned about alcohol consumption. I wonder what the family says. While it is true that it is harder to commit suicide by overdosing on the SSRIs & SNRIs, the suicide while on these drugs are usually much more violent. There are numerous cases on www.SSRIstories.com where people killed themselves by setting themselves on fire, etc. Here is a case that happened several weeks ago on Zoloft. First two paragraphs read: "Toxicology results on Chris Corna released this week do not change the Westchester medical examiner's conclusion that the popular Colorado restaurateur's death was a suicide, but police are not closing their investigation." "The car Chris Corna of Steamboat Springs was driving very early May 18 crashed into a bridge abutment after he slit his throat, the medical examiner said. A bloodied kitchen knife was found in the car. Either trauma was enough to kill him, Medical Examiner Millard Hyland said at that time." Paragraph four reads: "Hyland said today that toxicology tests found appropriate amounts of a medicine, a tranquilizer used to treat anxiety, were in Corna's system. The tranquilizer, sertraline, he said, is used in Zoloft." http://lohud.com/article/20090807/NEWS02/908070399/-1/SPORTS Suicide ruling remains in Colo. restaurateur's Port Chester death after toxicology results One suicide (from an already depressed person, with co-presence of alcohol) does not make SSRIs unsafe. The venlafaxine is more dangerous in overdose, true, but still relatively benign in its cardiotoxicity when compared to TCA overdose. As you state, you haven't heard too many cases where newish antidepressants were determined to the cause of death by overdose. This one, tragic, example, is not proof of this either particularly. Without getting patronising, anything is toxic and fatal in overdose. These drugs, although not perfect, certainly cannot be described as dangerous in overdose. Posted by: John at August 27, 2009 04:00 PMI don't know if the drug itself can be blamed if it was mixed it with alcohol. Posted by: Anna at August 27, 2009 04:33 PMIf you drink fifty liters of water, you'll die. So much for water being safe to drink. Tragically so. Posted by: Neuroskeptic at August 29, 2009 01:41 AMIf I had killed myself during the drug-induce ideations caused by Effexor I don't think it should be consider a suicide. If you don't see a problem with the amount of data available I believe you must be out of this planet. Posted by: Ana at August 29, 2009 02:38 PMWhether any substance can be toxic at ANY level isn't the point. Psychotropics can be lethal or disabling as prescribed for approved uses. when used as intended, and can permanently affect your brain function in deleterious ways. These are not benign substances that are well understood. Does drinking 1, 2, or 10 glasses of water somehow change and affect the brain to suggest drinking 50 liters to kill oneself? Does water compete with NTs? Does drinking physiological deliberate amounts of water alter the structure of the brain? Is drinking water (as a medical proposition) based on lies? Has drinking water been demonstrated to increase your risk of suicidality or suicide?
You could replace "water" with "SSRIs" and that would still be true - There is evidence that SSRIs raise the risk of "suicidality" in clinical trials but whether that translates into an actual increased risk of suicide which is still an open question. Anyway, that's not the point of Philip's post. The point is that SSRIs are extremely safe in overdose; they can be fatal in very rare cases, but they are vastly safer in overdose than most medications, including aspirin. Posted by: Neuroskeptic at August 31, 2009 02:01 AMI don't think you can readily substitute SSRIs with water in this context. Water isn't a brain disabling treatment. Does drinking 1, 2, or 10 doses of SSRIs somehow change and affect the brain to suggest consuming a vast quantity of SSRIs to kill oneself? A definite risk with SSRIs, not with water.
Yes, water no.
Yes, water no.
If one subscribes to the validity of the chemical imbalance/serotonin hypothesis, I'd say yes - water, no.
Suicidality definitely, suicide/homicide - quite possibly - water, no. In my experience, SSRIs are not especially safe in OD situations. Yes, more so than TCAs, but certainly not extremely safe. Most prescriptions contain sufficient amounts to kill with or without a catalyst. Granted there are almost always confounding factors which skew how reports get written. Many times, ODs are reported just so with no indication that a psychotropic was involved. I've seen this first hand. I initially believed this was to somehow "indemnify" the patient, but I've come to accept it is often to protect the treating psychiatrist. A lack of AE reporting does not infer drug safety. Posted by: Paul at August 31, 2009 07:57 PM"A lack of AE reporting does not infer drug safety." To add to your excellent point, Paul, most people with psych labels who report adverse effects are blown off as all complaints are blamed on the person's "illness" Actually, that is true with alot of reports of med side effects. There was a survey (I am too lazy to find the link) about people who reported cholesterol med side effects who were blown off by their doctors. But I think people with psych labels get dismissed the most. Can't believe those crazy folks. Sorry for getting off topic but I think you have raised some great points. Posted by: AA at September 1, 2009 03:23 PMI was not put on antidepressant because of depression or any other disease. I was prescribes "Tofranil" to help me withdraw Klonopin. YOU SHOULD POST THIS STORY ON YOUR SITE LET ME KNOW www.Drugawareness.org/recentcases/suspicious-suicide-of-sister FINALLY SOLVED DECADES LATER..JUST MONTHS AGO!! Posted by: l at September 28, 2009 07:39 AMPost a comment
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