August 17, 2009

Study: Antipsychotics Possible Treatment For Lung, Brain, Breast Cancer

A new study from Australian researchers in the International Journal of Cancer asserts that some antipsychotics can kill lung, breast and brain cancer cells. This was established in in-vitro lab experiments. The big winner among the cancer-killing antipsychotics is reported to be pimozide, otherwise known as Orap, an old first-generation antipsychotic that is among gnarliest in its side effects and is rarely used in treating schizophrenia (I have a friend whose mother has schizophrenia who was rendered catatonic on Orap). In second place was our old pal Zyprexa.

From sciencedaily.com:

"In the new study, pimozide was the most lethal of six anti-psychotic drugs tested by a team from UNSW and the University of Queensland. Rapidly-dividing cancer cells require cholesterol and lipids to grow and the researchers suspect that pimozide kills cancer cells by blocking the synthesis or movement of cholesterol and lipid in cancer cells.

"Analysis of gene expression in test cancer cells showed that genes involved in the synthesis and uptake of cholesterol and lipids were boosted when pimozide was introduced.

"To test the idea that pimozide acts by disrupting cholesterol homeostasis, the researchers combined pimozide with mevastatin, a drug that inhibits cholesterol production in cells. The two drugs were more lethal in combination against cancer cells than when either drug was used alone."

That's a fascinating finding, one that obviously needs to be replicated in vitro and in animal studies before finding any applicability to humans. But given how aggressive lung, breast and brain cancer cells can be--and how difficult they are to stop with current therapies--expect to see more studies of this potential use of antipsychotics in the fairly near future.

BTW, apparently what spurred this line of research was the observation that people diagnosed with schizophrenia who take antipsychotics had lower incidences of cancer, despite the fact that many people with schizophrenia smoke like chimneys, and researchers wondered if there wasn't some kind of cancer-protecting effect attached to antipsychotic use.

Obviously, these drugs are awful for people with schizophrenia over time and lead to a host of well-known problems such as diabetes and, well, you name it, but that's probably not relevant to whatever use antipsychotics might have in treating cancers, since patients would probably not take the drugs long term.

Posted by Philip Dawdy at August 17, 2009 12:03 AM
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Comments

Cool- fix the cancer, give 'em diabetes! That's horrible, I know.

Posted by: kimbriel at August 16, 2009 10:37 PM

That's seriously cool.

Posted by: NiroZ at August 17, 2009 12:32 AM

the back story...sure, maybe someone noted the lower incidence of cancer in ppl taking antipsychotics; but then again, maybe they noted the diabetes problems in ppl taking antipsychotics, and they now are trying to take lemons and make lemonade.

FS is great for bringing a lot of these stories to a broad audience.

It will be great to discover a new strategy for fighting cancer. However, it is sad that this phenomenon has been so greatly delayed. If pharmaceutical researchers had honestly acknowledged and explored the effect of antipsychotics, esp 'atypical antipsychotics,' upon the body's glucose management system, this phenomenon would have been discovered a long time ago.

Lancet recently published an article titled: "Avoidable waste in the production and reporting of resaerch evidence." while the authors do note an inefficient system (studies not published, etc.), I believe the waste is even greater. Whenever a new type of pill is invented, it may or may not work for its intended symptomatology. But researchers need to realize that outcomes may very well reveal even more knowledge, such as this antipsychotic med-cancer relation.

They did when they stumbled upon the antismoking effects of the antidepressant Wellbutrin. But they did not with HRT, they have not when ignoring suicidality in response to SSRIs/SNRIs in a portion of the populace, and they have not when exploring the atypical antipsychotics.

It is waste to hide, and to fail to explore, the data that rides along with your primary hypothesis.

Posted by: medsvstherapy at August 17, 2009 06:08 AM

What about pancreatic cancer related to diabetes? A cousin of mine died of that even though he took antipsychotics for several years.

Posted by: anna at August 17, 2009 07:20 AM

Peace be with you Philip

I'm not so convinced it would be a "short term" therapy. Besides the known addictive properties, and brain damage effects of those drugs, there is the fact that it has been proven profitable to medicate people for life on them. Orthomolecular medicine has been using vitamin therapy to cure cancer for fifty years. Where's that story?

Cancer is too profitable for the Pharmaceutical Corporations to just give someone a couple of years worth of Zyprexa. I believe it is a sale gimmick.

Humans only suffer two diseases - malnutrition and hypochondria. And, I believe one leads to the other.

love eternal
tad

Posted by: tad at August 17, 2009 07:58 AM

So anti-psychotic drugs kills cancer cells by blocking their synthesis of cholesterol and lipid.

Interesting hypothesis, oops theory.

Orap - Pimozide

Precautions:

"Clinical trials with pimozide indicate that it is not effective in, and therefore should not be used in the management of, manifestations of chronic schizophrenia in which the main symptoms include agitation, excitement and anxiety.

Sudden, unexpected deaths have occurred with pimozide, mainly at doses above 20 mg/day. ECG changes have been reported in association with the use of pimozide (see Adverse Effects), and one possible mechanism for the deaths is prolongation of the QT interval, predisposing patients to ventricular arrhythmia. An ECG should be performed before pimozide treatment is initiated and periodically thereafter, especially during the period of dose adjustment as one approaches dose levels of 20 mg/day. Any indication of repolarization changes, such as prolongation of QT intervals beyond 0.52 seconds in adults, or more than 25% above the patient's original baseline, or T-wave or U-wave changes, should be considered a basis for stopping further increases, possibly lowering the dose, and reviewing the need for pimozide. Caution should be exercised if it is necessary to use pimozide in patients with cardiovascular disorders.

Electrolyte imbalance, particularly hypokalemia, should be considered a risk factor.

Patients receiving pimozide should be observed for evidence of hypotension. Some individuals, especially the elderly or debilitated, have demonstrated transient hypotension for several hours following drug administration."

http://www.mentalhealth.com/drug/p30-o01.html

Posted by: Ana at August 17, 2009 10:45 AM

Well I agree with medsvstherapy that they could have discovered this effect earlier if they hadn't been so buisy trying to HIDE the metabolic effects of these drugs.

If it's true then at least if they're going to give me diabieties they might help keep me from getting cancer which runs in my family pretty strongly.

Posted by: katielou82 at August 17, 2009 11:48 AM

Don't get too carried away. Chemotherapy is to cancer what psychopharmacology is to mental illness, i.e. it's not benign and full of much of the same corruption. Grace Jackson has often said in lectures that antipsychotics are really chemotherapy agents. Think of so called "chemo brain." Just the same really as the way antipsychotics knock out the "psychotic." And allopecia, losing hair. Grace was told by her Navy shrink bosses that was because of the stress and "disease" but it was chemo effects. This is not entirely news.

Posted by: Sara at August 17, 2009 02:16 PM

http://www.furiousseasons.com/archives/2007/12/schizophrenics_at_highly_elevated_cancer_risk_due_to_antipsychotics_1.html

What about this?

Philip Dawdy responds: stephany thanks for bringing this up. i'm not sure what to make of this dicotomy....as well as my forgetting i'd run that piece two years ago.

Posted by: Stephany at August 17, 2009 03:25 PM

Thanks for musing about it with me Philip, I remember when you wrote it, like it was yesterday, it stuck in my mind, and from that 2007 paper:

"Patients with schizophrenia taking antipsychotics had a 308% increased colon cancer risk."

I think it's quite alarming and the 2007 paper I think was independent research, not pharma-funded.

It's like most studies we all read, they eventually cancel each other out it seems.

Posted by: Stephany at August 17, 2009 06:07 PM

"Typical anti-psychotics" will kill almost anything. They were developed as insecticides in 1935, and are now used in some states as part of a lethal injection on Death Row.
If you want to get rid of cancer, have a look at the work of Dr. Simoncini -
Candida Albicans cancer and fungus vs sodium bicarbonate - by Dr. Simoncini oncologist - Cancer and fungi
www.cancerfungus.com

Posted by: Lilly NC at August 18, 2009 09:24 AM
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