August 19, 2009

Glaxo Had Ghostwriting Program To Promote Paxil

The AP is out with a report that GlaxoSmithKline had a major ghostwriting program in place to help promote its anti-depressant Paxil.

"An internal company memo instructs salespeople to approach physicians and offer to help them write and publish articles about their positive experiences prescribing the drug.

"Known as the CASPPER program, the paper explains how the company can help physicians with everything from 'developing a topic,' to 'submitting the manuscript for publication.'"

"The document was uncovered by the Baum Hedlund PC law firm of Los Angeles, which is representing hundreds of former Paxil users in personal injury and wrongful death suits against GlaxoSmithKline. The firm alleges the company downplayed several risks connected with its drug, including increased suicidal behavior and birth defects....

"According to the memo, which dates from April 2000, the CASPPER program was designed to 'strengthen the product positioning and overcome competitive issues.'"

The AP reports that five published articles from this sleazy program appeared in print between 2000 and 2002 including ones published in the American Journal of Psychiatry and the Journal of the American Academy of Child and Adolescent Psychiatry. The specific articles are not identified. I think the journals involved either need to retract the articles or issue an explanation of why they contain sound scientific evidence. I suspect that the infamous Martin Keller-led Paxil Study 329 would be one of these papers. It was published in the JAACAP in 2001.

GlaxoSmithKline, Paxil's maker, claims that the program was discontinued several years ago.

Posted by Philip Dawdy at August 19, 2009 04:08 PM
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From the article, "Grassley and Sen. Herb Kohl, D-Wis., are pushing a bill that would require companies to disclose all payments to physicians over $100."

This would be a good start but wouldn't go nearly far enough. The public also needs to know how much money pharmaceutical companies give to advocacy groups like NAMI and how much this affects these groups' pro-labelling, pro-drugging stance.

Posted by: Francesca Allan at August 19, 2009 09:43 PM

From an 8/18 article in the Health section of the New York Times, Senator Grassley is also putting pressure on the NIH over ghostwriting. I hope something comes of that.

Posted by: Vicki at August 20, 2009 07:11 AM

The news that GlaxoSmithKline promoted the use of Paxil in children and adults through the ghostwriting of allegedly positive studies about Paxil has been reported before -- first in my book,
Side Effects: A Prosecutor, a Whistleblower and a Bestselling Antidepressant on Trial. The CASPPER program was part of that campaign to deceive doctors and consumers about the safety and effectiveness of Paxil and was unearthed by both Baum Hedlund (in the discovery process of several lawsuits) and by the New York Attorney General's office, which filed suit against Glaxo for consumer fraud in deceiving doctors and patients about the antidepressant. The NYAG's suit was settled in 2004 with Glaxo agreeing to post the results of all its clinical trials on a publicly available website, not just its ostensibly positive findings. All of this is detailed in Side Effects, which was published last year. For more info on the book and original documents pertaining to Glaxo's misleading promotion of Paxil, go to www.alison-bass.com.

Posted by: Alison Bass at August 20, 2009 03:56 PM

This doesn't surprise me in the slightest ..
If you research GSK , you will find a very dark history...
It disturbs me that this company sells , markets and distributes a huge margin of the worlds drug supplies..
I wouldn't trust any of their products..
What they did with Seroxat/Paxil is sinister..

Posted by: truthman30 at August 21, 2009 07:13 AM

http://bipolarsoupkitchen-stephany.blogspot.com/2009/08/1500-ghostwriting-documents-available.html

from the PLoS website:

"If you are an editor, author, reviewer, or reader of medical journals, or if you depend on your doctor or health care provider getting unbiased information from medical journals, then the 1,500 documents now hosted on the PLoS Medicine Web site should make you very concerned and angry [1].

Because, quite simply, the story told in these documents amounts to one of the most compelling expositions ever seen of the systematic manipulation and abuse of scholarly publishing by the pharmaceutical industry and its commercial partners in their attempt to influence the health care decisions of physicians and the general public.""

Posted by: Stephany at August 21, 2009 10:50 AM
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