May 29, 2009

Holland Refuses To Approve Seroquel For Depression

According to Reuters, the Netherlands Health Authority, acting as a reference body for the European Union, shot down AstraZeneca's application to have Seroquel approved as a treatment for depression.

"The Dutch decision to refuse approval for the medicine in MDD, because of a negative benefit-to-risk balance, comes after Seroquel XR won partial support from U.S. advisers as a treatment for the same condition last month."

AstraZeneca has submitted its application to the European Medicines Agency. The drug was reportedly approved for depression in Canada last month (news to me).

Posted by Philip Dawdy at May 29, 2009 10:46 AM
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Comments

The approval of Seroquel as an "add-on" for depression is extremely dangerous because the physician will then usually add the Seroquel to an existing cocktail of an SSRI and a benzodiazepine.

Stan White is a man from West Virginia whose son [a soldier] died in his sleep. The son was taking a combination of Seroquel [an atypical antipsychotic], Paxil [an SSRI] and Konopin [a benzodiazepine].

Stan White is researching and has found more cases. I think he is at either 9 cases or 12 cases where the soldier was taking a combination of Seroquel, an SSRI [ all cases were Paxil with the exception of two - one was Zoloft and one was Prozac] and a benzo. I think several cases might also have involved pain killers.

Stan White now has a list of 39 soldiers who died in their sleep. The last I heard, three days ago, he was attempting to have these 39 cases analyzed to determine what medications these soldiers were taking.

Here is more on the case as it appears on SSRI Stories.
--------------------------------------------------
http://ssristories.com/show.php?item=2572

First paragraph reads: "A Putnam County veteran who was taking medication prescribed for post-traumatic stress disorder died in his sleep earlier this month, in circumstances similar to the deaths of three other area veterans earlier this year."

Paragraph 3 reads; "Military doctors prescribed Paxil, Klonopin and Seroquel for Johnson, the same combination taken by veterans Andrew White, 23, of Cross Lanes; Eric Layne, 29, of Kanawha City; and Nicholas Endicott of Logan County. All were in apparently good physical health when they died in their sleep.


http://wvgazette.com/News/200805230640

May 24, 2008
Vets taking PTSD drugs die in sleep
Hurricane man's death the 4th in West Virginia
By Julie Robinson
Staff writer

By Julie Robinson

jul...@wvgazette.com


Posted by: Rosie at May 30, 2009 01:39 PM

It's no guarantee that they won't approve it in the future, or in other European countries.

I just watched a German TV-doc the other day, disclosing Eli Lilly to have bribed the researcher responsible for the approval of Prozac in Sweden back in the 1980ies with 20,000 dollars. Prozac gets approved, although there's huge concern in regard to its potential to cause suicidality. In 1988 Germany refuses to approve Zoloft for the same reason. The next year, Germany approves Zoloft anyway. No one knows what had brought about this sudden change of mind, but there's only one explanation: $$$...

The program is here: http://www.zdf.de/ZDFmediathek/content/644434?inPopup=true , a transcript here: http://frontal21.zdf.de/ZDFde/download/0,6753,7007662,00.pdf (both in German)

Posted by: Marian at May 30, 2009 05:19 PM

*Smile*

Posted by: Lilly NC at May 30, 2009 10:42 PM

This blog is frightening. If you have a mental disorder, I don't think reading this blog is good for your brain.

Philip Dawdy responds: thanks for reading and thanks for commenting.

Posted by: Frank Lee Disgusted at May 31, 2009 07:35 PM

Wow, Mr. Lee. Do you not trust yourself enough to winnow out the wheat from the chaff, to see what fits your situation from what doesn't, to grapple with life's shades of gray? Learning to do that is one path to mental health so this site has been invaluable to me in that regard.

If you're commenting on others' inability to do that, well, that's really none of your business, is it? No one has elected you arbiter of other people's recovery.

Posted by: Sherry at June 1, 2009 05:50 AM

I couldn't disagree with you more, Frank. This blog has been of immeasurable benefit to me and my "mental disorder."

Posted by: Francesca Allan at June 1, 2009 09:23 PM
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