I feel like puking after learning this news. As I was reading the collum I wondered if the price of Vanda Pharmaceuticals was going up. Jokingly thought one should invest in the company. 824%, 8 times your money now. Psychiatry is legal slavery. Did you have the news of drug approval before the stock market knew? Financial Investors (psychopathic) should be reading this website to know when to buy and when to sell their pharma co. stocks.

What changed is the medical reviewer who turned down iloperidone was forced out of the Psych group a few weeks later.

This drug has been investigated since the early 1990s and changed hands several times. I am unsure why Novartis was not able to bring it to market. Usually when a promising drug has undergone multi-million dollar trials and subsequently not made it to market, there are either failed trials (lack of efficacy) or safety concerns. The path of iloperidone to market has been extremely atypical. I suspect that the manufacturer has been trying to walk the tightrope of getting the lowest possible doses into labelling in order to minimize disclosure of tolerability or safety concerns. This is just my speculation, time will tell.

Given the early development and its long history, I wonder just how much patent life there is left in this medication?

Philip - I'm on it. I'll be searching PubMed for you and doing my best to decipher what I am capable of deciphering (I'm no psychopharmacologist, nor doctor but I have done a lot of self educating and taken a few classes). If I get any abstracts that are written in understandable english I'll pass them along. If I find anything that looks fishy to me I'll post it here in the comments on this post and maybe someone who's more edumacated than I can tell us all exactly what the heck the people writing the abstract are talking about.

Part of the initial rejection, I think, had to do with Vanda's attempt to pair the medication with a genetic testing protocol to determine if a person was likely to respond to it. That, and the fact that it was not as efficacious as Risperdal. It seems that the approval was along the lines of "well, at least we have another medication to offer." All the same side effects as the established atypicals. Old wine in new bottles.

Fanapt?
I guess they did a terrible choice.
Fanatic.

It may sounds silly but they really spend time trying to find the right name and to make it more scientific uses X,Y and Z a lot:
Prozac, Zoloft, Zyprexa, Abilify...

The financial markets sure liked the news: Vanda's stock price reportedly exploded 824 percent higher in after hours trading.

So everything is great. When we finally accept that these are the people these drugs are created for we will be at peace.

Dear Lord!
People are dying I said DYING, committing HOMICIDES and SUICIDES - even children - under these drugs.

THEY DON'T CARE.
Stakeholder and Shareholders are the master of the world.

I'm sorry for saying the obvious but some people come here for the first time.
I received two comment that made me see how far people are from knowing these data.
Sometimes raising awareness means writing as if you just started to discover it.
I don't remember but I'll make an effort to try to remind the feeling of the first suicide I became aware.

Existing anti psychotics are going generic .. they need a new cash cow ... fanapt is a joke

http://www.thestreet.com/story/10497618/1/surprising-approval-for-vandas-fanapt.html

also dont forget that Obama's FDA Commissioner is due to be appointed soon... they got this out of the way before that ... the greedy neocons probably making money by drugging children ...

This is just another disgusting filthy toxic compound that governments are going to force feed to distressed... and label them with pysch labels, and poison the hell out of them. It's neurological vandalism, pure and simple... fucking with neurology, without any diagnostic biotechnology, it's pathetic, an embarassment to medical science, it should be condemned by all members of pure medicine.