January 15, 2009

New Antipsychotics Found To Create Risk Of Cardiac Deaths

I keep wondering when the many pieces of bad news around the atypical antipsychotics will finally wake up patients and doctors to the unacceptable dangers of these drugs and lead to decreases in their use. Now comes this study from the New England Journal of Medicine identifying that people who take atypicals have a more than 200 percent greater chance of a fatal heart attack than people who don't take the drugs. That really ought to make doctors (and parents) think twice about giving these drugs to children, the elderly and anyone who doesn't have a psychotic disorder. A doubling of cardiac death risk is kind of hard to ignore.

When these drugs were introduced in the 1990s (Abilify came in the 2000s), they were touted as wonder drugs, antipsychotics that were risk free and safe for one and all. Now, it's clear these drugs cause all kinds of metabolic problems, diabetes, heart problems, prolactin problems and on and on the list goes. They've killed thousands, more than Vioxx. So widely-used are these drugs for a myriad of conditions that their sales in 2007 were $14.5 billion, a huge increase from the $2 billion in antipsychotic sales rung up in 2000. The growth was because these drugs were supposed to be good for absolutely every psychological malady and their were prominent psychiatrists saying so.

I wonder how they all feel now. I wonder how they now explain away giving these drugs to someone. Here's what one of the study authors said:

"'Any prescription is a balancing of risks and benefits. This is more information on the risks that needs to be taken into account,' [Wayne] Ray [study author] said in a telephone interview.

"'Many people thought the "atypicals" would be much, much safer. Our study suggests that they are not at all safer in regards to this serious end point,' said Ray."

I've only been saying this for three years now.

I swear the atypicals have turned out to be one of the biggest scams Big Pharma has ever pulled on Americans. They also represent a big black eye for psychiatry, which worked so hard to adopt their use and defended the drugs to the hilt.

Posted by Philip Dawdy at January 15, 2009 12:03 AM
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"I swear the atypicals have turned out to be one of the biggest scams Big Pharma has ever pulled on Americans. They also represent a big black eye for psychiatry, which worked so hard to adopt their use and defended the drugs to the hilt."

Exactly! Anyone recently prescribed Abilify for depression as an add-on med to their med cocktail should think twice--it's only being offered as that now because it's the new campaign to push the drug's use--boldly ask your psychiatrist why it was rx'ed--and my bet is they won't have an answer.(except possibly because it's the latest "idea" (or pharma rep talk).

I did this. Before I left my psych's office after discussing in length (for months now) my grief over what happened to my daughter via the wrong dx for pediatric bipolar and the medications--here is what I asked: "What are you prescribing now for depression, and mostly to women?" (DTC ads are blatently going after women)

"Abilify, and as little as 1 mg. seems to be helping some ppl. as an add-on med."

Whatever works.

I appreciated his candid answer and willingness to have a provocative discussion; it's why I go talk to him.

Posted by: Stephany at January 15, 2009 02:06 AM

From the article:
"'Any prescription is a balancing of risks and benefits. This is more information on the risks that needs to be taken into account,' [Wayne] Ray [study author] said in a telephone interview.

Risks and benefits?
BENEFITS: The physician's.
RISKS: All ours.

Posted by: Lilly NC at January 15, 2009 04:26 AM

I wonder how many psychiatrist's would give an antipsychotic to their own child.
If one told me yes they would, I'd ask; how about for something like anxiety (only when going to school)?
I have no doubt that prescription would not be written so fast. I'd guess 90% of the time, not written at all.

Posted by: Becky at January 15, 2009 04:38 AM

When clozaril, the first 'atypical,' came out, the claims were that it was better than traditional antipsychotics (i believe the leaders at the time were prolixin and haldol) because the side effect profile was not as bad, AND because it seemed to help 'negative' (flat affect etc.) psychotic symptoms, as well as 'positive' symptoms (hearing voices, etc.). Turns out it was all just marketing hype?

Posted by: MedsVsTherapy at January 15, 2009 06:23 AM

Clozaril hasn't stopped my daughter from hearing voices, and the side effects are life threatening to the point by law mandatory blood tests every 2 weeks. I'd like to say these drugs were efficacious and worth their risk.........

Posted by: Stephany at January 15, 2009 10:16 AM

Stephany, I have friend who's on Abilify and swears it's the best thing that's happened to her. In fact, she's become so convinced of how great it is, she's trying to get ME on it!

Posted by: Marissa at January 15, 2009 06:54 PM

I think Phil is right that these medications should be reserved for those with psychotic disorders. Only then is the benefit-to-risk ratio acceptable (but not great) considering the high rate for suicide in this population. The risks are just too great for using any antipsychotic in non-psychotic patients.

Posted by: Tony at January 16, 2009 12:17 PM

RE"psychotic disorders"
We still have a problem.
Who defines psychotic disorder?
Am I having a psychotic disorder?
No/Yes ?
How do the drugs work to stop it?
How much drug do I need? Is it too much or too little?

Posted by: Mark(p.s.2) at January 17, 2009 12:01 PM

A person who is found to have a "psychotic disorder" by one expert might be found to not have one by another. I think it is too much power for any single individual to have to be able to make a decision like that about another person's life. Maybe the person who has to incur the risk should be allowed to know ahead of time what that risk is and be allowed to decide for themself if the risk is worth whatever benefit they may get from that particular pill. And maybe they should be offered less risky alternatives first.

Posted by: Kent at January 17, 2009 08:53 PM
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