December 08, 2008

Psychiatrists, Scientists Editorialize In Favor Of Legal Use Of ADHD Drugs In Healthy People

Two psychiatrists, some neuroscientists, ethicists and the editor of Nature opined in the journal yesterday that America needs to grapple with the "responsible" use of performance-enhancing brain drugs in healthy people. One of the authors is Ron Kessler, a psychiatrist and public health wonk at Harvard who has previously argued that roughly 50 percent of Americans have a DSM condition of some type. He was also behind a study that came out this year and asserted that adults with ADHD/ADD cost their employers 22 workdays a year. The other authors are largely unknown to me.

A summary of the piece reads:

"Society must respond to the growing demand for cognitive enhancement. That response must start by rejecting the idea that 'enhancement' is a dirty word, argue Henry Greely and colleagues."

The piece itself begins:

"Today, on university campuses around the world, students are striking deals to buy and sell prescription drugs such as Adderall and Ritalin — not to get high, but to get higher grades, to provide an edge over their fellow students or to increase in some measurable way their capacity for learning. These transactions are crimes in the United States, punishable by prison."

And, then it goes behind the subscription firewall, so I hope to see the full piece later today (someone send it on over please).

It sure is funny, though, that they begin their argument citing the examples of college students illegally using ADHD drugs (meaning they aren't prescribed by a doctor for ADHD/ADD). College students like to smoke a lot of pot too and that's illegal. Are Greely and colleagues going to call for the legalization of weed? Or is that off limits because it's not considered an "ethical" pharmaceutical? And isn't this the same age cohort that psychiatrists claimed last week had an almost 50 percent prevalence of mental disorders? And they are the springboard for this argument? The kids doing "college crack?"

The AP had a bit more of the commentary:

"'We should welcome new methods of improving our brain function,' and doing it with pills is no more morally objectionable than eating right or getting a good night's sleep, these experts wrote in an opinion piece published online Sunday by the journal Nature."

Interesting point, but it'd be a lot more interesting if the drugs in question weren't ADHD stimulants--the use of which has led to dependency, withdrawal issues, addiction to other drugs, heart problems and psychosis--and Provigil, the narcolepsy drug about which we know very little in long-term use. I'd be a lot more comfortable if they were talking about natural compounds which no one could patent, because these kinds of arguments are Big Pharma's wet dream.

One of the authors told the AP that demand is out there among middle-aged sorts who want to improve their memory and multitasking workers, and that everyone would want to take Adderall, Ritalin and newer versions of the same kind of drugs. So college students and corporate types will now be the justification for making psych meds available to one and all, even absent an identifiable psych disorder? Sounds pretty damn weird to me. And others.

"But the commentary didn't impress Leigh Turner of the University of Minnesota Center for Bioethics. 'It's a nice puff piece for selling medications for people who don't have an illness of any kind,' Turner said."

Can you imagine what the advertising would look like for these drugs? It'll likely be a variation on Viagra and other ED drug ads, only this time with one's brain and not one's pecker as the concern.

The authors also called for:

"While supporting the concept that healthy adults should be able to use brain-boosting drugs, the authors called for:

— More research into the use, benefits and risks of such drugs. Much is unknown about the current medications, such as the risk of dependency when used for this purpose, the commentary said. Also, according to the Food and Drug Administration, Adderall, for example, is an amphetamine that carries warnings about possible sudden death, heart attack and stroke, especially for people with heart problems.

— Policies to guard against people being coerced into taking them.

— Steps to keep the benefits from making socio-economic inequalities worse.

— Action by doctors, educators and others to develop policies on the use of such drugs by healthy people.

— Legislative action to allow drug companies to market the drugs to healthy people if they meet regulatory standards for safety and effectiveness."

While this is all provocative and interesting and wonk-worthy, didn't America go through a period of time when doctors handed out stimulants to fairly normal people looking for a boost? Yes, those were the 1960s, when Benzedrine and other stimulants (which certainly resemble speed or cocaine in their actions, because they are similar in their structures) were handed out like candy by doctors. Soon enough we had an epidemic of people hooked on "uppers" and the feds moved to sharply curtail their use (they were made controlled substances).

Personally, I don't know where I come down on this issue because I am generally OK with intelligent adults making decisions about what compounds to put in their bodies, but at the same time I see tons of problems with the thrust of the authors' argument. Can't we just be who we already are and leave it at that?

I guess this whole thing boils down to what one considers enhancement and what price they are willing to pay to be enhanced, or if they are willing to do the hard work of improving themselves without a booster drug. If these scientists can make the case for uppers, then what's to stop them from also making the case for "downers" and arguing that it's OK for otherwise healthy people to be given some Seroquel? What about Oxycontin?

Ah, the possibilities are endless.

Posted by Philip Dawdy at December 8, 2008 12:03 AM
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Comments

When we hoped for more responsible prescribing practices we once again find that it is all about "growing the market."


It will be interesting to see how persons choosing to take prescribed ADHD drugs for "performance enhancement" fare when seeking to purchase life, health and disability insurance.

Posted by: Joe at December 8, 2008 06:16 AM

I put this on my site yesterday as well, but I was horrified when I saw it...

Yeah, in theory I'm open to the idea that "responsible" adults can do what they want with their bodies, but this is just another mass addiction waiting to happen...

I mostly just share the sentiment, "Can't we just be who we already are and leave it at that?"

I think the more we put toxic mind altering chemicals in our bodies on a regular basis the further we get from our true natures and any ability to be with who we really are.

It's true that if any drug were used occasionally there would be no need for concern, but we know that the drugs in question here are highly addictive...this is an insane idea to entertain as being appropriate for anyone who wants "enhance" their brain...I think one would do much better in the long run by enhancing themselves with good food and meditation and clean living, but again we see the short cut being pushed here...

Cocaine was once heavily pushed by doctors as well...we see history repeat itself again and again except the stakes keep getting higher...and more and more of the population included.

Posted by: Gianna at December 8, 2008 06:38 AM

Philip,

Thanks so much for posting on this--a friend forwarded the article to me this morning and I couldn't believe my eyes.

Now that I've come to terms with the reality of the piece (unless it's a cleverly disguised hoax of the Sokal variety), I find myself deeply ambivalent. The piece seems to challenge two widely held and deeply ingrained attitudes towards drug use. On one hand, it's an off-the-cuff acknowledgment of the fundamental disconnect between seeing self-enhancement with drugs as unethical and seeing drugs as a necessary part of human natureculture. But on the other hand, as you point out, Greely and company really don't seem to care about the fact that we (scientists, philosophers, social scientists) are really, really far from having any clue of how these drugs are working on our bodies or what kinds of damage they are (or are not) doing.

But in either case, I think the issue of drug use--psychiatric, performance-enhancing, recreational, or whatever--really complicates the issue of medical ethics, especially in the domain of mental health. Who counts as "mentally competent," and who has ethical and financial access to psychopharmaceuticals?

I'm really glad that you were one of the first to pick up on this article, since the debate is firmly anchored in cultural hypocrisies having to do with who we are, who we can be, and who we're supposed to be. Thanks for all your great work.

Posted by: Brad at December 8, 2008 08:37 AM

"Society must respond to the growing demand for cognitive enhancement. That response must start by rejecting the idea that 'enhancement' is a dirty word, argue Henry Greely and colleagues."

Why don't they say it all:

The human brain is not well designed and need some fixing. As a matter of fact the human body is not... blah blah blah... you must go to the doctor to know what drug you must take. Your body must be adjusted.

It seems that "a pill for every ill" is in the past.
Now it's time for a pill for every action.
I would like to know when the pills for iatrogenic diseases will be on the market.

The conspiracy to make people believe they are not fine is endless.

Posted by: Ana at December 8, 2008 01:28 PM

This is just weird and really rather disturbing coming from Nature which is quite a prestigious publication. One thing that it puts pay to is the argument I remember reading in Hallowell's book Driven to Distraction that you can tell who really has ADHD by whether the medication works or not. Yes, that was the diagnostic criterion he finally ended up with after blithering his way through a number of other very iffy and subjective behavioral symptoms to determine just who has ADHD and who doesn't. So now suddenly we find out that they work for anyone (we all must have ADHD) -- as if anyone who has half a brain didn't already know that. This stuff, as one friend put it, is "time release meth or cocaine." I've called them "steroids for the brain" and another moniker is "math pills." Yeah they work really well for perseverative, task oriented assignments but watch out for any creative, playful, imaginative side to your personality and be ready for some nasty depression down the road if you don't have heart problems or psychosis first.

Posted by: Sara at December 8, 2008 03:53 PM

This article is absolute capitalist grossness. Perhaps we should be asking ourselves why our society is set up so that people have to take drugs in order to get a "competitive edge" and finish college or stay awake while sitting in a cubicle for 8 hours a day. Okay, so great, everyone gets high on speed so they can "multi-task" like robots with Microsoft Windows for brains. What happens when the whole thing falls apart because all college kids and the corporate workforce have turned into tweakers?!

Posted by: David at December 8, 2008 05:01 PM

It is odd to think of a society where everyone takes speed all day. I wonder if these folks have interviewed any one who has been awake for three days due to amphetamines to see how much their "performance" is "enhanced."

Posted by: Sally at December 8, 2008 07:05 PM

According to an article in the Washington Post a couple of years ago:

Although the drugs may allow people to stay awake longer and finish work faster, scientists who published a new study concluded that about 1.6 million teenagers and young adults had misused these stimulants during a 12-month period and that 75,000 showed signs of addiction.

The study found that both men and women were equally likely to be misusing the drugs, but that women seemed to be at greater risk of dependence -- characterized by a lack of control, physical need and growing tolerance for the drug -- while men seemed to be at greater risk of abuse, in which the medication was used in dangerous situations, said lead author Larry Kroutil, who studies health behavior and education at RTI International, a nonprofit research group.

You can find the entire article at:

http://www.washingtonpost.com/wp-dyn/content/article/2006/02/24/AR2006022401773.html

As a woman who was prescribed Adderall for several years to "augment" my increasingly useless high-dose antidepressants, I will say that physical tolerance shows up fast, and the addiction can be ruthless. Of course, it does help you lose weight... but so did Dexedrine in the 1960's. And so does crystal meth.

Posted by: Johanna at December 8, 2008 07:43 PM

People should just leave people alone. If some want to take these drugs and are causing no harm to others then it's none of anyone else's business. It amazes me here at how many seem to know what's best for everyone else.

Posted by: A Believer at December 9, 2008 02:54 AM

The point, A Believer, is that the health of each and every one of us as individuals actually depends very much on the health of the community as a whole so even if you think something you take isn't doing any harm to anyone else you might just be wrong. It doesn't do any of us any good at all to have a bunch of unhealthy people surrounding us. And would you say the same thing about heroin, cocaine, methamphetamine etc.? Someone might take any or all of these things and ostensibly not be harming anyone else but he really is by incurring the loss to society of his own well being.

Posted by: Sara at December 9, 2008 10:16 AM

This weeks issue of TIME, dated December 15, in the Briefing section on page 13, shows a graph: 45.79% of college students have psychiatric problems, 47.74% of non-college students have psychiatric problems. I'm getting a little tired of hearing about how people are more "screwed up" than they really are. Is individualism dying before it's had a chance to really catch on?

Posted by: Andy Alt at December 9, 2008 03:55 PM

STOP the WORLD, I WANT to get OFF. Or at least slow it down, pretty please.

Posted by: Sophia at December 10, 2008 09:26 AM
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