October 08, 2008

Pfizer's Data Manipulation Of Neurontin For Bipolar Disorder, Headaches

My back is still out, so briefly I want to make you aware of an article in today's New York Times about how Pfizer allegedly cooked the books on neurontin, an anti-seizure drug the company was all hot to have used for bipolar disorder, headaches and so on.

"The drug maker Pfizer earlier this decade manipulated the publication of scientific studies to bolster the use of its epilepsy drug Neurontin for other disorders, while suppressing research that did not support those uses, according to experts who reviewed thousands of company documents for plaintiffs in a lawsuit against the company.

"Pfizer’s tactics included delaying the publication of studies that had found no evidence the drug worked for some other disorders, “spinning” negative data to place it in a more positive light, and bundling negative findings with positive studies to neutralize the results, according to written reports by the experts, who analyzed the documents at the request of the plaintiffs’ lawyers."

Pfizer did most of this in the early years of this decade and, separately, settled off-label marketing claims with the feds for $430 million in 2004.

Posted by Philip Dawdy at October 8, 2008 10:59 AM
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So all of those people who were considered treatment resistant and given even worse drugs, ect, and locked up, or some combination of the three, might not have been treatment resistant, just taking drugs that don't work. People need to go to prison over this sh*t, press releases, public apologies, financial restitution to the folks harmed and of course their psych records cleared.

Posted by: Sally at October 8, 2008 11:10 AM

So this leaves me with a gut ache wondering about my Dad taking Neurontin for neck pain, and having the drug be one that came back in his system after he was killed in his plane crash.

I've read of other people becoming psychotic on this drug, manic and agitated and all the while being prescribed for pain.

Off label use of medications like these is risky business, but to read that data is skewed, frankly leads me to feel beyond upset at how many innocent people could or have died on meds like these, and no one ever knows to investigate the drug for cause of DEATH.

Posted by: Stephany at October 8, 2008 11:27 AM

Dear Philip:

Neurontin {I used to call it your-rotten} was marketed directly to doctors through golf vacations, fishing trips, Hookers, and under the table expensive gifts for off label use before any studies or approval was given by the FDA many years ago. The studies they had at the time showed it was less effective than a placebo for psychiatric conditions. But when you’ve got the Money train running so smoothly and well oiled, why not do as much damage as possible while you’re getting richer and richer at others health and expense. You just got to Love Big Pharmaceutical; there motto should read "you take it; we rake it, the rest we can bury later".

Yours Truly,
Stan

Posted by: stan at October 8, 2008 04:11 PM

What's great about the Times piece is that it puts this latest scandal in context: "The expert reports.. add to accusations that the pharmaceutical industry has controlled the flow of clinical research data, blurring the lines between science and marketing."

It's getting harder and harder for apologists to claim that problems are the result of just a few 'bad apples' when evidence keeps piling up that the industry is maggoty to the core.

Posted by: UnderTheThresher at October 8, 2008 07:10 PM

Prescription Access Litigation has posted copies of the Neurontin documents that were released in this case, and that documented the alleged manipulation of Neurontin studies, on our blog here: http://blog.prescriptionaccess.org/?p=304. Makes for an interesting read.

Posted by: Prescription Access Litigation at October 16, 2008 06:20 AM
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