September 05, 2008

Cymbalta, Seroquel Being Investigated By FDA For Overdose, Urinary Problems

The FDA is just out with a list of drugs it identified as having major issues which the agency needs to investigate, based upon data from the first quarter of the year. Two psych meds make the list of 20 drugs and I list them below with their approved use and the problem being investigated:

"Cymbalta, for depression and other conditions, urinary retention.

"Seroquel, for bipolar disorder, overdose due to sample pack labeling confusion."

Urinary retention sounds like a perfectly awful side effect of an anti-depressant. But then so do overdoses of Seroquel. Other drugs on the list are OxyContin, Heparin and Dilantin.

It'll be interesting to see what the FDA turns up.

Posted by Philip Dawdy at September 5, 2008 12:16 PM
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Comments

It wasn't so long ago that pharma was pushing urinary retention as a benefit of Cymbalta. Let's not forget that Traci Johnson was in a clinical trial for urinary incontinence, NOT depression, when she died. They were trying to get duloxetine (its scientific name) approved for that, not depression. Duloxetine has been paraded out for all sorts of crazy indications since it first came on the scene umpteen years ago in an effort to find a market for it. Wouldn't you know it finally found its home in the psych world as so many drugs with no obvious place to go do?

Posted by: Sara at September 5, 2008 02:48 PM

elavil(amitriptyline) is used for urine retention too.

Posted by: jenna at September 5, 2008 04:04 PM

This just infuriates me, due to the fact that Traci Johnson died as a healthy young college-age student seeking money from a drug trial in Lilly's lab for urinary incontinence!.

To push the drug for use for depression and pain management is downright criminal and greedy.

I find this urinary retention a sad ironic twist to Traci's story, and her story should be a warning for anyone entering a drug trial, especially vulnerable young people. Lilly is far too close to a college campus, I hope those kids understand the dangerous practices Lilly does to promote their medications.

Lilly, the creator of one of the most dangerous and deadly psych meds ever marketed: Zyprexa; and Cymbalta is their next one that is practically impossible to withdraw from.

Posted by: Stephany at September 6, 2008 04:11 AM

Psychiatric attendants and parents want their wards sedated but they don't like changing sheets?

Posted by: Sally at September 6, 2008 06:57 AM

The clinical test Traci Johnson has volunteered was also to test as an antidepressant but it was not said to her neither to the four others volunteers that has also died.

"According to an investigation by the London Independent newspaper, all five deaths were "hidden" by the American Food and Drug Administration (FDA). The FDA gave a legal rationale for its silence: "Some clinical trial data are considered 'trade secrets', or commercially protected information, and thus are exempted from release under the Freedom of Information Act."

This is from Independent back on 2006 in a good article with an interview with Peter Bregguin who was in Ireland.
I've copied this article on my blog because of what Peter Bregguin says and what they say about this murderous clinical trial.

I'm happy knowing that Cymbalta side effect is urinary retention.

Good job FDA! Your work is getting better year after year!

We have to admit that they do a wonderful job concealing the truth and mixing informations.
Congratulations FDA!

I would also like to thank FDA for helping selling psych meds around the world.

Many countries put on newspapers FDA's views on some drugs. People don't know what FDA stands for and as it's a REGULATOR AGENCY everybody think that being approved by FDA is a safety guarantee.

Posted by: Ana at September 6, 2008 08:56 AM

PS: Let's not forget the first Elli-Lilly's creation:
PROZAC!

Posted by: Ana at September 6, 2008 09:16 AM

The Cymbalta clinical thrial for duloxetine that Traci Johnson was doing was for "Stress urinary incontinence" - "a condition in which women leak urine with they laugh or sneeze" and the duoloxetine brand name is Yentreve.
When duloxetine is for depression the brand name is Cymbalta.
the other 4 volunteers that has died were depressed and testing the drug for depression.

It's all explained here:
http://www.ahrp.org/infomail/05/09/27.php
on
SLATE
Drug Secrets
What the FDA isn't telling.
By Jeanne Lenzer
Posted Tuesday, Sept. 27, 2005

Traci's body was found dead in February, 7 2004 and Cymbalta was on the market in August, 2004.

I never found the name of the other 4 volunteers who were depressed and committed suicide on Elli-Lilly's facilities.

Posted by: Ana at September 6, 2008 12:05 PM

I think this list is feeble and far from complete (even Seroquel is not being examined for much, and there are no killer antipsychotics or SSRIs here) but this little requirement did get put in the new PDUFA bill, I think, so I guess the FDA has to make the gesture. Pharma probably doesn't like it.

Posted by: Sorrowful at September 6, 2008 12:22 PM

One more MAJOR negative for Cymbalta but unrecognized (except by those who have been taking it). It makes many users out of control drinkers. Check out: http://www.steadyhealth.com/Increased_alcohol_use_on_Cymbalta-t81623-0-asc-0.html

Posted by: Bill at September 7, 2008 06:21 PM

Never take Seroquel as an occasional sleeping
pill. Never ever, unless you want to look
out of your mind that particular day. You
will sleep but you will not sleep. You might
feel rested when you wake up but once you go
outside you will feel like everything you
see is an offence against you. Imagine
what it does to you once you get "accumulated".
I was awake for weeks when I took it so I can
say that it saved my life but I don't know
if I was doing myself a favor or not by
just taking 50 mgs.

Posted by: Neuronoise at September 12, 2008 05:51 PM

"One more MAJOR negative for Cymbalta but unrecognized (except by those who have been taking it). It makes many users out of control drinkers. Check out: http://www.steadyhealth.com/Increased_alcohol_use_on_Cymbalta-t81623-0-asc-0.html
Posted by: Bill at September 7, 2008 06:21 PM "


Blanket statements like this are scare tactics and should be avoided by ANYONE. I've been on Cymbalta for over a year and truthfully for my fibromyalgia pain it has been a MIRACLE drug. Sure, I'm scared shitless to get off of it due to the "scare tactics" of people posting their experiences of withdrawal but it's working and no large ill side effects (blood tests drawn every three months). I was recently put on Seroquel for bipolar in addition and I was researching information on other people's experiences and came across this. I've now decided the INTERNET is the not the place to be looking for for that information.

I don't drink, and find it offensive for someone to place blame for certain individuals uncontrolled addiction on a DRUG.

Posted by: Dee at July 22, 2009 02:22 PM
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