August 05, 2008

Estrogen Therapy For Schizophrenia

A new Australian study in the Archives of General Psychiatry is out, bolstering earlier research showing a therapeutic benefit--ie, less psychosis--for women diagnosed with schizophrenia. It's an add-on treatment and, of course, not super helpful for men with schizophrenia (who generally are diagnosed with schizophrenia more than women are) and it's not entirely clear to me how great the benefit is for the women in terms of symptom improvement (I've not seen the full paper), but this is the first decent bit of news I've seen on the schizophrenia front in like forever. This relatively thin Reuters piece also covers the study.

The research on this is still in its infancy, but I have no doubt that some docs will start experimenting on their own. Of course, estrogen treatment essentially amounts to what's known as hormone replacement therapy and HRT has turned out to have all sorts of problems of its own, so it will be interesting to see where all of this goes. Maybe the day will come when Fuller Torrey will write op-eds demanding that women take their estrogen and be forced to do so.

Just wondering aloud: would testosterone replacement therapy have any benefit for men with schizophrenia?

Posted by Philip Dawdy at August 5, 2008 12:03 AM
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Gotta wonder if this is an attempt by Pharma to keep
a questionable drug in circulation.
That said, please do a search for schizophrenia + niacin + hoffer - and also look for the articles on schizophrenia at http://alternativementalhealth.com/

Posted by: Lilly NC at August 4, 2008 11:20 PM

docs already use hormones for mental health issues all the time...but generally it's not psychiatrists doing it...it's integrative and some alternative docs...

The rage in those circles are bio-identical hormones...which supposedly are safer though there really is no research to back the claims.

The hormones mentioned in the article, I believe are the synthetic variety.

I've actually tried progesterone and it fucked with me...progesterone is used a lot for PMS and menopausal symptoms...as is estrogen some of the time

hormones shouldn't be played with lightly---they are very powerful and they are delicately balanced...adding a bunch of this or that can be very risky...

Posted by: Gianna at August 4, 2008 11:37 PM

Man oh man, this really frosts my cupcakes. First you were writing about Viagra for women. Now this?

I cannot help wonder, it's almost 4 am here and my brain is racing from lack of sleep. The conclusions I am getting- wow.

You know in my mother's generation, which is probably a lot of mother's generation of your readers Philip, they took out the entire female reproductive system when they thought women were going through menopause. Now they do it chemically, not surgerically. I remember my mother was in a lot of pain from the surgery and completely uncomfortable by the estrogen her doctor made her take.

It doesn't seem that long ago in my abnormal psych class Hamlet's Orphelia was labled a Hebephrenic Schizophrenic. They don't use that label anymore either. I have it on fine authority that now she is considered Bipolar in today's lit classes.

My father grew up in the age if a woman was depressed you get her a hat. I wonder if that will come back in vogue too. I cannot use a hat, but I could sure use a new pair of shoes.


Anyway, I am rambling and I am sure I am making no sense tonight to anyone, so I will bed you all a good night.

Posted by: susan at August 5, 2008 12:51 AM

Actually, hormones play a huge part with misdiagnoses, and often can shift a violent person into a calmer state if the hormones are out of whack.
My daughter happened to have 10times the normal amount of testosterone in her body and that was when she was violent.
Corrected by birth control pills. During that aggressive time psychiatrists attempted to "control" the aggression with Seroquel (didn't work) and I insisted on bringing in the hormone tests. Well what do you know, they came back out of whack.
Many psychotic events for ppl (men can be included in this, but talk about uncharted territory for data)are triggered by hormonal imbalances, and also is why some women have psychosis and PMS ---it's not rocket science.

But psychiatry doens't involve treating the whole body, it just slams down brains with chemicals when other things could be happening.
Not often is there an epidemiologist on a psych ward, hardly even a medical doctor can be found.

Posted by: Stephany at August 5, 2008 07:39 AM

That should read endocrinologist. It's worth going to one before a psychiatrist in my opinion.

Posted by: Stephany at August 5, 2008 09:54 AM

One more thing--men with low testosterone levels are often dx'd with depression and medicated for that via antidepressants and wonder why they don't find relief. It's hormones.

Posted by: Stephany at August 5, 2008 09:56 AM

Risperdal caused my pituitary gland to swell, and the pituitary regulates hormones. They almost put me on hormones before they realized this. This causes me to be concerned with all of these women diagnosed with mental problems having their possible hormonal imbalances being iatrogenic.

Posted by: Sophia at August 5, 2008 10:56 AM

But psychiatry doens't involve treating the whole body,
Stephany

Yep! They don't know how to manage a labirinth problem.
have you noticed that they don't ask for blood exams to check anything?
I like GPs.
Down here they don't prescribe psychotropics and it's always good to have a good GP around.

Posted by: Ana at August 5, 2008 02:17 PM

Most of the antipsychotics out there cause an increase in prolactin, which is a hormone and it probably effects other hormones. I know it can decrease testosterone levels, so maybe it increases estrogne levels, and maybe that is part of how these drugs work... but you'd never know it because psych docs rarely think about the part that hormones play in mental disorders.

Posted by: BipolarBunny at August 5, 2008 02:35 PM

Just thinking out loud, sex hormones effect mood. Could the decrease in sexual functioning caused by these drugs somehow effect estrogen and testosterone levels causing some of the other bad side effects we see?

Posted by: Sally at August 5, 2008 03:07 PM

What about hormons in men's Schizophrenia ?
Please give me an answer !


Thank you!

Have a nice day!


Brigitte for Yan !

Posted by: Brigitte at May 24, 2009 08:40 PM
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