August 26, 2008

Canadian Doctors Ignore Warnings On Antipsychotics

Between 2002 and 2007, Canadian health regulators issued a slew of warnings on the use of antipsychotics in the elderly--so did American regulators between 2004 and this year--and yet the use of drugs like Zyprexa, Risperdal and Seroquel actually increased among the elderly, according to a new study in the Canadian Medical Association Journal.

"'The three warnings about serious adverse events associated with use of atypical antipsychotic agents in elderly people with dementia had a limited effect on the prescription rates of these agents,' [writes] Dr. Geoffrey Anderson of the department of health policy, management and evaluation at the University of Toronto.

"'We also found that the overall rates of use of these drugs actually increased between the first warning in 2002 and the end of our follow-up in 2007.

'This finding highlights the limited impact of warnings and suggests that more effective approaches are needed to protect vulnerable populations from potentially hazardous medications.'"

Keep in mind this was almost all off-label use as well and the use of these drugs exploded in the US despite warnings about dangers associated with their use. Makes you wonder what it takes to get a doctor's attention? Perhaps regulators ought to be hiring hot pharma rep types and send them off to doctors' office with Reese's Peanut Butter Cups.

Posted by Philip Dawdy at August 26, 2008 12:03 AM
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As hard as I fought for warnings on antidepressants - and I still think they are important - I have come to the sad conclusion that they made little difference in prescribing habits with the possible exception of a few short months at the end of 2004, going into 2005. And maybe Paxil became somewhat less popular - relative to other antidepressants - with physicians (probably more from their own observations than the publicity that surrounded the warnings that specified Paxil a lot). It's going to take a lot more than a few words surrounded by heavy black lines to stop the momentum towards using these drugs for every little concern out there. They are just too convenient in terms of shutting people up and giving them little hits of sedation or stimulation. Let's just hope that people are becoming a little wiser about some of the adverse effects when they arise.

Posted by: Sara at August 26, 2008 08:38 AM

I am kicking myself in the ass for responding here, but I want to make sure readers know another perspective to this issue with use of antipsychotics in the elderly.

Go to nursing homes, to homes where family members are housing an infirmed, demented parent or grandparent, or to day programs that work with senior citizens, and listen to the sheer number of people who not ask, but clamor or demand meds to intervene with the disruptive behaviors that inevitably occur with dementia, chronic medical illnesses, and just boredom or resentment by these people who have been basically abandoned by family and the community. Again, it's this quick fix mentality that gets shoved in our faces as psychiatrists to quiet, control, manage people who are almost always victims of illnesses or cultural abandonment that is beyond drugs. Unfortunately, too many psychiatrists are too happy to oblige and write for antipsychotics because they'll do the job: sedate, impair, and chemically redirect. That's one reason why I do not do much geriatric work these days; people do not want to hear there are behavioral and interpersonal interventions that are equally if not intially needed before meds are introduced. So, again, rail at the psychiatrist for providing the service screamed for, or , perhaps, rail at the society that asked for it in the first place.

you know what is going to be on my gravestone: No good deed went unpunished. That is my epitaph since I started medical school. Become a doctor, then rail away at me because you do know better because you've done better!

Posted by: therapyfirst at August 26, 2008 01:32 PM

I am aware of the circumstances in nursing homes. I have a colleague who knew that an antipsychotic given to her mother would probably kill her but felt the situation was so dire that the drug was warranted. But I have to take exception at a psychiatrist (above) feeling sorry for himself for knowingly causing death, no matter what the circumstances. I know a psychiatrist who knowingly caused the death of my child, and I know what I would like to put on his gravestone.

Posted by: Sorrowful at August 26, 2008 03:37 PM
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