June 17, 2008

Paxil On Trial

Ed Silverman at Pharmalot has an interesting interview today with Alison Bass, formerly a reporter at the Boston Globe, who's dug into the epic story of bad medicine and deceit that is the Paxil story and written a book called Side Effects: A Prosecutor, A Whistleblower and A Best-Selling Antidepressant on Trial.

Here's a snippet:

"Pharmalot: What was the most surprising info you came across while researching the book?

"Bass: What I found most surprising was they doctored the research on the Paxil study. When I looked back at memos I received from the Institutional Review Board from Brown, teenagers were withdrawn from the study and called non-complaint when they were in suicidal as a result from Paxil and should’ve been counted in the study as adverse effects. If these had been appropriately coded, there would have been an even greater risk of suicidal effects from Paxil. That was really amazing. There were many indications this Paxil study, it was called study 329, was doctored. But because it was published in a prestigious medical journal, Journal of the American Academy of Child & Adolescent Psychiatry in 2001, doctors paid attention."

I've covered the Study 329 nonsense previously. Bass also has her own website, which is here.

Posted by Philip Dawdy at June 17, 2008 01:40 PM
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Comments

There's a typo in that quote. It should be non-complIAnt, as in stopping the drugs because they are making you feel bad, not non-complAInt. Pretty important concept so just wanted people to be clear on that.

Posted by: Sara at June 17, 2008 02:58 PM

This is a sick country if this is how we find out raw data is manipulated, withheld just to make a buck while placing children in danger!

Good, let's just all write a book about what we know and that way doctors and the FDA won't ever have to do a damn thing!

This infuriates me to no end.

PEOPLE DIED BECAUSE OF STUDY 329

Posted by: Stephany at June 17, 2008 05:29 PM

Wow, I mean wow. What scumbags.

Posted by: Sally at June 17, 2008 05:32 PM

I'm reading Alison Bass's book Side Effects and it is excellent, much better than I expected from one review I read. She brings a lot of the players (like Martin Teicher) in the antidepressant fiasco to life, recounts the FDA hearing from 1991 on Prozac in detail and goes into the story behind Spitzer's suit against GSK. Wow! It is really a page turner and reads like a thriller. I strongly recommend it. If there was any doubt that the evidence was there well over a dozen years ago that SSRIs are bad medicine this book dispels that. And shows that the (corrupt) machinations by the pharmaceutical companies have been going on for a very long time.

Posted by: Sara at June 21, 2008 09:42 PM

I would like to tell everyone about my experience with taking Paxil. I am doing this so that you may make an informed decision should you decide to take this drug. I was not given that option because certain side effects, though known, have not been disclosed to the FDA, physicians, or consumers.
I was prescribed Paxil by my doctor during an especially stressful time in my life. I had no history of mental illness nor was I diagnosed with an anxiety disorder. I took this medicine, actually a very low dose, from 2001 – 2005. When I decided to stop taking it, I cut my dose back gradually and weaned myself off of it entirely.
I began having gastric distress. This began as I was cutting back on the Paxil and continued long after I quit taking it. I had diarrhea every day for 2-1/2 years. Just about everything I ate went right through me. This lasted all day long, every day. From my research, I have since learned that most of the serotonin in your body is located in your intestines, so it makes sense that if you take something that adjusts that serotonin level, then your intestines would be affected.
I will try to tell you how this has changed my life. It affects everything that I do, from what kind of job I have, where I go, vacations, where and what I can eat. I have had many tests run by specialists and there is no other cause for the diarrhea. I can also tell you that there have been some very embarrassing moments because of this.
About 2 months ago, as an experiment, I started taking the Paxil again. And guess what? The diarrhea stopped almost immediately. I found a blog called Paxil Progress, which is a blog for people who are trying to wean off of Paxil and it seems that my story is not unique at all. This drug causes bowel incontinence, bloating, horrible gas and pain along with the chronic diarrhea.
I wish I had known what this drug would do to me before I started taking it. Please do your homework. The doctors will not tell you about the side effects and withdrawal symptoms, nor will GlaxoSmithKline, the makers of Paxil. Can you guess why they don’t tell you? $$$$$$$$$$$$$$

Posted by: Sheila at August 12, 2008 02:16 PM
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