April 25, 2008

Anti-Depressants And "The Trying Game"

As the bad news continues to build in the scientific literature about how weak anti-depressants are, some researchers continue to pound on the idea that if at first an anti-depressant doesn't work, then try, try again. Here's a newish paper from Biological Psychiatry (abstract is on this page) wherein researchers do a meta study of four previous studies and find that for people for whom a first line SSRI doesn't work, then switching to a non-SSRI anti-depressant is slightly more efficacious than trying a second SSRI--28 percent remission versus 24 percent.

Reuters thought this study was sexy enough to merit an article, but there's a point where I just begin to shake my head. The best study looking at the what to do after an anti-depressant fails is STAR-D--and in that study each try at another anti-depressant produced weaker and weaker results, all the way down to an 8 percent remission rate on the fourth try. That tells you a lot about the nature of depression and of anti-depressants.

Speaking of this current study:

"The results indicate that current treatments for depression are still less than ideal. 'There continues to be a pressing need to introduce new antidepressant medications,' comments Dr. John Krystal, the journal's editor."

I assume Krystal isn't thinking of Pristiq and I hope to God he isn't thinking of antipsychotics as the new anti-depressants (don't laugh: Seroquel's maker has submitted three separate applications to have the FDA approve its gnarly drug for treating depression), but I think docs ought to be looking to something other than new anti-depressants for their hope. Like maybe CBT. But maybe it's expecting too much to get that talk from the editor of Biological Psychiatry.

I'm not being dismissive of treating depression, but there are limits to where meds will get most people. I had to face up to that fact a few years ago and I think my life--physically and psychologically--is better as a result. But that's just me.

Posted by Philip Dawdy at April 25, 2008 12:03 AM
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Comments

What pisses me the most about this whole SSRI scam is the fact that it is widely held knowledge in psychiatry that depression will pass on its own without intervention in 4 out of 5 cases. Psychiatry doesn't advertise this fact, neither does pharma of course.

But they do advertise and advocate these meds as a be all and end all solution or "cure" for depression. If 4 out of 5 cases of depression will lift of their own accord, why do they target everyone whow suffers from it with psychiatric drugs?

They portray depression as if it's AIDS or Cancer, some kind of uncontrollable fatal illness. They use evocative language to push meds, such as "depression is life threatening" , "the plague of depression" , "depression is a disease" , "depression is a chemical imbalance"..

They have bastardised the condition and medicalized it when in fact in the majority of cases it is a totally legitimate rection to the trauma of being human and will run its course without drugs. Depression, like all human experiences, exists for valid reasons. To medicalize it is to exploit it.

So if 4 out of 5 cases of depression will run their course and pass eventually then what of the 1 in 5 which might need treatment?...

The 1 in 5 individual is usually so desperate for some relief that he or she will be easily coerced into the mediation route.

Of course the "depression exploiters" such as psychiatrists and pharma give the impression that there are "options" for depression treatment. They usually say there are 3 options for depression -

1. Medication (with therapy)
2. Psychotherapy (on its own)
3 ECT (electric shock)

So , the depressed individual now thinks there are three options for treating their condition.
But..
The reality is there are few therapists available in a public health system, and long waiting lists, so the depressive is rarely even offered psychotherapy as an option at all.

Drugs are what are prescribed.

ECT is given as an "optional" last resort..
But one could hardly call this barbaric procedure a "choice"...

ECT is highly dangerous and has been described by some psychiatrists as "brain damaging"..
Of course , they don't advertise this either..
ECT can have long lasting mental scarring far worse than the orginal trigger for the depressed mind. It can have cognitive and memory damage. It is similar to a lobotomy and is one of the most inhumane acts any human being could be subjected to..

The psychiatrists know that there will be a certain ammount of people who will be so desperate that they will consider it and these people are vulnerable and easy to persuade..

It is also one of the most profitable aspects of the psychiatric regime and is used more as a threat to control patients than anything else..
Some psychiatrists claim it works..
And arguably you could say it does...
Unfortunately this temporary "relief" comes with its a new set of problems...
Charging shocks of voltage through a persons brain , so much to induce a seizure is bound to "snap em out of it right"?...
Unfortunately, not only does it zap away the depression, it also zaps the persons personality and memories.. It causes an irrerversible brain injury...

So , is ECT an "option" for depression?..
Would anyone in their "right" mind choose to be brain damaged?


There are other more effective and less severe and danaging solutions for depression such as lifestyle changes, diet etc ..They don't advertise these either, because you can't patent an "attitude" but you can patent an ECT machine and an anti-depressant...

Psychiatrists hve no interest in empowering the individual who suffers from depression because that would end the profession of psychiatry , a profession which is reliant on pharma, drugs and ECT...

Instead they actively and deviously promote these disempowering treatments which cause more harm than depression ever could...

Shame on psychiatry...
Evil Bastards...

Posted by: truthman30 at April 25, 2008 03:59 AM

"Prozac might cure "lazy eye", scientists say"
Thu Apr 17, 2008 3:04pm EDT
http://www.reuters.com/article/scienceNews/idUSL1662871820080417

"Vetencourt said the ability of Prozac and perhaps other SSRIs to return neurons to a more plastic state could, in theory, mean they might also have a role in other neurological disorders in which synaptic plasticity was compromised, including Alzheimer's disease."
:o)

The DSM-5 Agenda Researcher focus on children:

" ...the roots of many chronic mental disorders, such as antisocial personality disorder, schizophrenia, mood, and anxiety disorders, are found in childhood; "
" 2) Prevention and early intervention: studies of early intervention for children and adolescents; (3) Improved diagnostic classification of disorders of infancy and early childhood;
(6) Developmental epidemiology: large scale population-based samples of children studied from birth, or even earlier, through adulthood. "

I'm really scared. I guess it will never stop.

Posted by: Ana Lima at April 25, 2008 05:42 AM

truthman30,
ECT is a treatment in Brazil.

People with Major Depression - the real disease - are treat this way after switching from an antidepressant to another.

I don't know what kind of medicine is this.

Posted by: Ana Lima at April 25, 2008 10:57 AM

When I started complaining and crying about my job, saying my boss was treating me unfairly, and I didn't know a reason why he would do this, I was prescribed Risperdal, and anti-psychotic. They said this was to treat "some paranoia." This was a very destructive drug for me, along with all the myriad others that were prescribed. It didn't make me think my boss wasn't being mean to me, but it did make me not care. A therapist noted that that wasn't such a substantial help, but didn't recommend that I go off it. Then later, I developed a tolerance to it, and, um, I did care. I am so scared to death to go on anything now, after what happened to me. Having issues with work shouldn't be medicalized either, in my opinion.

Posted by: Sophia at April 25, 2008 08:03 PM

I agree. After my long comment to another entry, that's all, I agree.

Posted by: Sally at April 26, 2008 02:12 PM

It took 6 anti-depressants before one worked for me.


The first 3 - all SSRIs - nada.


The next was an SNRI but it sent me manic.


Next one - worked somewhat, didn't give me a manic episode, but not enough.


Venlafaxine - bingo! It works, in conjunction with my lithium, without sending me into the stratosphere either. Have been on it for almost a decade.


Had my doc decided after 4 meds not to bother, I'd be dead, or still in the hospital, 10 years later...


I've had lots of CBT. It's great. I view it as the equivalent of diet and exercise in treating type 2 diabetes. Some people can control their diabetes with this alone, hold the glucophage. Others MUST have the meds, as their diabetes is worse and diet and exercise alone won't keep their blood sugar in the right range. The diet and exercise really help, but the blood sugar has to be kept under control too.


I get very annoyed with well-meaning folks lecturing me that I don't need my meds, because with them, I've had and continue to have a reasonably successful, normal life. Without them I screwed. (I know you're not doing that btw. But the anti-med brigade have seized on the latest bunch of stories here in the UK like you wouldn't believe).


And there is NO WAY I am taking olanzapine or quetiapine instead of an anti-depressant. I experience little or no side effects from anti-depressants. Can't say the same for anti-psychotics, when I have encountered them. Big pharma, meet my big stick (waves stick ineffectually).

Posted by: DeeDee Ramona at April 27, 2008 10:04 AM
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