March 01, 2008

Weekend Update. Plus: Linkorama

A couple of things. Thanks to the reader (or was it readers?) who threw the bipolar blood test post of a few days ago up on StumbleUpon yesterday. I've been getting slammed with hits ever since. Speaking of hits, February was a record month for this site. I cannot even begin to thank people enough for reading my brain vomits.

On the fundraising front, Friday was successful day and so was Saturday morning. Donations totaled $463 which brings the total for the winter fundraiser to $1,013, halfway to the goal for the fundraiser of $2,000 by the end of next Friday. I thank you all for your contributions. I won't mention money again until Monday.

Meanwhile, Danny Carlat has an excellent post in which he savages Pristiq, Wyeth's allegedly new anti-depressant--it's just a metabolite of Effexor, not much else. The FDA approved Pristiq yesterday for the treatment of depression. Carlat thinks the old wine in a new bottle offering from Wyeth is pretty much what you'd expect from wine that wasn't so swell in the first place: damn little. For those of you who are new to Carlat, he's a psychiatrist, a professor at Tufts University and once upon a time went out and did doctor talks for Wyeth on behalf of Effexor. The latter was a move he's regretted and wrote about in the New York Times. Anyhow, Carlat is uniquely positioned to critique the new old wine and I have a hunch that some party balloons went flat in New Jersey when the Wyeth folks read the very lukewarm responses to Pristiq's approval.

Pay particular attention to what Carlat writes about the drug's performance relative to placebo. The way things are going these days with news of how weak the anti-depressants have been that have been approved by the FDA over the last two decades, I figure if I could get the money together I could drum up two clinical trials establishing the efficacy of bourbon in treating depression and get approval of Kentucky Prozac by the FDA. I am only half-joking.

BTW, what is it with all these metabolites of old drugs being approved as "new" drugs the last year or so. In late-2006, Invega was approved to treat schizophrenia and it has proven to be a complete dud. Now comes Pristiq, daughter of Effexor. Is this the best we can do 20 years after the advent of Prozac? Has psychopharmacology run out of gas? The Wall Street Journal has a piece in which people basically pooh-pooh Pristiq.

One SSRI is proving to have a very long half-life in court. A woman from British Columbia is suing GlaxoSmithKline, alleging that Paxil gave her daughter birth defects. Sigh.

Speaking of meds, here's the press release from AstraZeneca announcing its move to have Seroquel approved by the FDA to treat depression. What's odd is that usually in these sorts of press releases the company will talk about how well the drug has performed in pre-approval studies, as AZ did when it had studies of Seroquel's performance in bipolar depression pre-approval. So why the silence now? If your drug rocks so hard that you think it can pass muster as a standalone anti-depressant why aren't you waving that big old AZ flag for all the world to see?

Let me continue to point out to readers that the slow mission creep of antipsychotics as monotherapy or adjuncts for depression should scare the beejesus out of one and all. If a doc waved an antipsychotic in front of me to treat depression, then I'd go running for the hills.

The Washington Post has a book review up about a book touting the good side of depression.

Stay tuned. If I have the time and energy, I may put up a post tomorrow about Lilly's pretrial moves in advance of a scheduled trial of the company over its handling of Zyprexa in Alaska.

Posted by Philip Dawdy at March 1, 2008 02:08 PM
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Comments

Dude, if you can get Kentucky Prozac approved for use by the FDA, I'll start screaming at insurers to add Jefferson's, Woodford's and Blanton's to their covered prescriptions and we'll ALL be happy :)

Posted by: Puckett at March 1, 2008 07:53 PM

"Let me continue to point out to readers that the slow mission creep of antipsychotics as monotherapy or adjuncts for depression should scare the beejesus out of one and all."

It's beyond comprehension it has gone this far, and in fact is going to create a new world rx junkie.

From snorting Seroquel to selling it on the streets; antipsychotics are going to damage generations of people--you cannot turn back once it starts and it has begun. Abilify, Risperdal, Invega, whatever the package name says, it's still a product that needs a black box warning and a FDA mandatory backstep to correct their error in protecting citizens, when the reason they don't have a black box is "data based on demented elderly".

Watch the Frontline PBS Medicated Child again, and listen to the FDA spokesman tell the truth about that on camera.

I believe it's time for the headlines to read :

"Antipsychotics, antipsychotics you need to know you're on antipsychotics." and bypass the failure of anti-depressant news, and get the public watchdog alarm sounding LOUDLY about what they are being replaced with as we speak.

Rebecca Riley was 4 yrs old and was on Seroquel,[and died] and it doesn't matter how or why as much as why was a doctor allowed to rx it to a child in the first place?

Posted by: Stephany at March 1, 2008 09:04 PM

What's mental illness but psychosocial distress which is then put into a state a perpetuity by the simple power of suggestion that a psychiatrist has in his authority. You are told you have a disease and must be hypervigilant about certain symptoms, and then you begin to experience them materializing, and begin to come to believe when you hadn't before, that your entire self, mood, whatever, is being controlled by some phantom disease, that has chosen to attack you.

The unblinking fanatical, faith based biological determinism, as applied to so called mental illness, presents the trained eye with nothing but a constant glossy pile of pseudoscience dressed up in big pharma money, and anything purporting to be 'science' coming from the mental health field, is not worthy of your attention.

The state sanctioned monopoly given to biopsych for dealing with psychosocially overwhelmed people is obscene, and there is no rationale for forced administration of toxic agents to anybody. Protection from self or others and restraints or incaceration should extend as far as restricting psysical movement of the target only, and be a police matter, no doctor's who understand the mind exist in the world, i hate to tell you, any needle or pill forced into this person's biology, constitutes neurological rape, and the application by force, by the state, of unproven psychiatric ideology, and toxic agents into a person's organism. It is abhorrent, and heinous criminals are treated better than the first presentation psychotic.

Psychosis' biopathology is not understood at all, and no specific targeted biological treatment exists, so any claimed rudimentary version of such an agent should not be forced by the state on the innocent.

The myth about coercion that goes around is that the state is protenting you from self or haring others, but that is only half the story. If the state locked you in prison/restraints, as it does, than that would be the end of what is described in coercion. But that is not the case, the state, is telling you, and the world that you have biological disease when it forced biological treatment, declaring this as 'fact' and impacting your life for years to come and not to mention your body, now when as a society or as individuals, or as families, are we going to demand a hire standard of evidence that we have a biological problem requiring biological treatment, because all we have now is a bible, a clergy, a stack of theology papers, televangelism ads, and toxic holy water and blister packs full of eucharists, and a heap of fanatics with mouthpieces, and call to prayer a few times a day.


When, oh when, are you people going to see...you've changed your view of yourselves, of your neighbors, your very identity and past, present and futures, all from the power of suggestion.

Whatever alledgedly tangible problem say you have, it's just a construct and you know it, deep down, you just have to dig your way out. If you've got parkinson's disease, neuroscience can maybe help.

If you get involved with psychiatry, your life is going to be shorter than it otherwise would have been. Simple as that. The proble is people are not warned of the risks of psychiatry, and that is why they are gullible prey.

Psychiatry preys on people when they are at the lowest ebb, when they are the weakest. It applies toxic agents to them, which invariably reduce cognitive function, and in this diminished state, task these people with coming to grips that they suddenly have a life threatening disease, which psychiatry cannot see, identify the cause of, predict the outcome of, cure, prevent, even prove that it exists, and is not visible on the autopsy table.

The society hands psychiatry the mantle of authority for dealing with overwhelmed people, and in an increasingly secular and scientistic (yes that is a word people) we will defer to experts or those presented to us as experts more and more unquestioningly, and when they tell us we have a disease, the power of suggestion is at work, but it appears to be an actual disease, it's a negative placebo effect kind of phenomena.

This is what is happening to all of you who claim you have a disease which is found in the DSM.

You feel and experience the mood swings because you been turned into a hypervigilant and neurotic individual, conditioned and disempowered of your self determination by buying into psychiatry's ideology, which is a faith based ideology which can offer you absolutely no objective, heavily replicatable, honest, scientific basis, for a fucking thing that has been said to you.

This viscious phenomena, if it has gone on too long, you'll be so heavily invested in it, in time and effort and commitment to your patient identity, that you'll immediately lash out and say I am wrong. But I am right.

Psychiatry is the greatest peacetime threat advanced society has ever faced, and I truly hope, that one day you'll join me, and the world can live as one.

Posted by: Billion at March 2, 2008 07:04 AM

I agree that anyone who watched the Frontline show on The Medicated Child or read Benedict Carey's series on kids on antipsychotics must be shaking their head in disbelief that this stuff is still being approved for kids. Honestly between stimulants, antidepressants, and antipsychotics (and I'm sure there are others) a whole generation is at risk -- I cannot even begin to imagine where we are going to be in 10, 20 or 30 years. The health issues that we will be facing boggle the mind.

Posted by: Sara at March 2, 2008 08:08 AM
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