January 02, 2008

Risperdal Depression Study Slammed, Seroquel XR To Get New Indications?

As most readers know, Big Pharma is sure interested in having its anti-psychotics used for treating depression. While I cannot argue with the short-term use of atypicals for treating depression, I find it appalling that we could well have a situation in this country where people are taking two sets of unpredictable, dangerous drugs (anti-depressants and atypicals) for long-term use when real world experience would argue against the long-term use of these drugs. Anti-psychotics are not safe for long-term use, pure and simple. Doctors who have their patients on these drugs long-term are doing them a profound disservice.

Anyway, CL Psych has yet another post on the infamous ARISE study of Risperdal's use in depression. A psych doc wrote a letter to a journal challenging the study which led to an interesting exchange with the study's author. Well worth reading.

Meanwhile, AstraZeneca has filed two applications with the FDA to have Seroquel XR--the extended release version of its atypical anti-psychotic--approved for treating mania and bipolar depression. In a press release, the company claims that bipolar disorder affects 4 percent of American adults, a claim that is largely without support. NIMH pegs it at 2.2 percent.

But then America's pharmaceutical companies can say pretty much anything they want and get away with it.

Posted by Philip Dawdy at January 2, 2008 11:00 AM
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Comments

While I cannot argue with the short-term use of atypicals for treating depression,

huh?? did you mean to say that?? I can't imagine any time an atypical would be good for depression. Atypicals are by their very nature depresssing They sedate the hell out of you and depress cognition if nothing else.

Did you mean mania? I can see allowing for extremely short term use for acute manic and psychotic states, but that's as far as I can imagine them being used legitimately.

Depression? Never.

Posted by: Gianna at January 2, 2008 12:45 PM

yes i actually did mean to say what i said. i think anti-psychotics can be useful for some people who are suicidally depressed and agitated beyond all measure. once upon a time, they were used by psych docs to treat just such a situation but with the injunction that they only be used for a couple of days in order to get whomever off the floor or ceiling as it were. now the atypicals are being pushed for long term use, ie, 'prevention,' and the distinction i am tryign to make is that atypicals have their place in very short term use, but that they are almost worthless longer term.

Posted by: Philip Dawdy at January 2, 2008 01:05 PM

agitated depression, okay. yes that can be dangerous--i suppose it could be argued such a state is a "mixed" state. I wouldn't call that simply depression.

Posted by: Gianna at January 2, 2008 01:16 PM

Brief use for psychotic depression, maybe. Anything else, no way.

Posted by: Sorrowful at January 2, 2008 02:47 PM

And AstraZeneca has already indicated they are going after generalized anxiety disorder and, it appears, depression, for Seroquel.

4% prevalence rate for bipolar -- that's setting the bar low. Lilly pegged it (and maybe still does) at 6% when they were promoting Zyprexa. As for any having any basis in reality, well, marketing is based on what you can convince others to believe, not what is actually true.

Happy New Year, Philip.

Posted by: CL Psych at January 2, 2008 02:52 PM

The problem with treating any of the "disorders" of the DSM is that they don't actually exist. They are names given to grouped observed behaviors.

The APA admits they don't know what causes these disorders.

Where does one end and another begin. How would you correctly decide how to treat someone with more than one disorder?

There is circumstantial evidence that depression is an outcome of Subliminal Distraction exposure. There is no drug capable of treating this problem. It is a form of operant conditioning.

There is no recognition of this phenomenon and no drug testing eliminates this exposure when evaluating drugs.

The seminal case for this exposure as a cause of depression is the mass insanity event on the Belgian Polar Expedition of 1898.

Posted by: L K Tucker at January 2, 2008 03:23 PM

Seroquel XR- March 07.

Seroquel has short term use qualities; long term, it's no good. But, as most of the literature states, nothing is really measured beyond a 6 week trial. It's up to the patient to learn and identify what drug works for them, just like Tylenol vs. Advil.

It's an informed consumer that knows how to use this stuff. It's the little kids like Rebecca Riley, dead at age 4 who we need to focus on here.

The watered-down DSM bullshit is going to kill/injure a much larger innocent population than the ones commenting here.

Posted by: Stephany at January 2, 2008 06:11 PM


They just added Seroquel to my med mix for anxiety.


Doc didn't even care that I said diabetes ran in the family and I am scared to take this med. Just take it and be a good girl.Then he gave me a box of samples to get me started for a New Years Present.

I hate docs and I hate meds.

Posted by: susan at January 3, 2008 04:48 AM

Susan,
Read the stuff at the Last Psychiatrist on Seroquel before you take it. You may decide to try some benedryl instead.

Good luck and best wishes. I too, hate docs and hate meds. I avoid both like the plague. I'm trying to get better at "yessing" them. It's a matter of self preservation, I think.

Posted by: Sherry at January 7, 2008 05:09 PM
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