December 20, 2007

Cymbalta Pain Treatment Claims Overstated?

I just ran across an interesting abstract in the current Psychotherapy and Psychosomatics--I'm still trying to get the full paper, so if anyone has access pass it along please--in which a psychology professor went back through various studies where Cymbalta--Eli Lilly's latest blockbuster anti-depressant--was alleged to have an effect on pain in depression and found that the claims were inflated. I have never, ever heard of Lilly making overstated claims for their medications before, so I am shocked (shocked!) to learn that this might be the case:

"Results: Across five trials, the results indicate a very small (d = 0.115) and statistically nonsignificant (p = 0.057) analgesic effect for duloxetine. Additionally, some of the relevant data on duloxetine's effects have not been reported fully, making it likely that the obtained results reflect an overestimate of its true impact on painful physical symptoms in depression. Discussion:The current analysis is based on a small number of studies; further trials may yield significant results favoring duloxetine. Based upon the currently available evidence, the marketing of duloxetine as an antidepressant with analgesic properties for people with depression does not appear to be adequately supported."

So I guess that "Depression Hurts" TV ad campaign which Lilly spent hundreds of millions of dollars on is bogus too.

Ironically, the Journal of Clinical Psychiatry just published a paper on Cymbalta in which the authors claim:

"These results support duloxetine's efficacy and tolerability in the treatment of pain and depression in patients with at least moderate pain associated with depression."

Based upon Cymbalta's approval for depression and depression maintenance much less the treatment of neuropathic pain and the claims about physical pain relief that the company makes as well as a new level of dispute in the academic literature about those claims, I think the FDA needs to examine Lilly's claims and decide whether the company is making legitimate claims in its marketing.

From what I know in the patient community, people who were given Cymbalta for chronic back problems--which seems to be the rage amongst some docs lately--experienced no relief, but plenty of side effects including liver damage, agitation, suicidality and withdrawal symptoms. They were being given the drug because some pain management docs are running scared of the DEA's anti-opiate campaign.

Thoughts?

Posted by Philip Dawdy at December 20, 2007 12:03 AM
StumbleUpon Toolbar del.icio.us Digg it reddit
Comments

Yes, I have thoughts, and here they are in this post based on some research I did inspired by Puckett using Cymbalta for pain management.I researched from 1976>2007. Opiates, etc.

Note that AstraZeneca is quoted in my post as wanting to... "AstraZeneca has a goal to become the leading company in pain control"...look out Lilly, ya have company comin' over.

enkephalin: Pain Killers: 1976>2007>AstraZeneca Feels Your Pain.

Posted by: Stephany at December 20, 2007 12:35 PM

The whole Cymbalta campaign has been built on the "drug for depression and pain" idea...

It is an absolute disgrace what Lilly are doing, not only are they quite content to exploit "depression", but they are also smugly satisfied with exploiting the aches and pains that go with it...

Just when you think that the pharmaceutical companies can't go any further down the unethical gutter, they come fresh with new ways to con the public ...

Posted by: truthman30 at December 21, 2007 11:02 AM

If you go to youtube and type in 'Cymbalta, an evil drug' Youtube user dianicwolf, explains her painful and lingering withdrawal off that drug on video.

v=3KdtaFmDTA0

I have recurring neck and middle back pain from several car accidents. An anti-opiate campaign is just pure Pharma at it's finest.

Codeine is the only pharma drug that really makes the pain go away and leaves me with side effects I can handle.

I would never trade it in for a psych med. Especially after hearing one woman's testimonial on withdrawing from it.

Posted by: Jane at December 22, 2007 10:39 AM

free the poppy.

Posted by: Lily at December 22, 2007 05:38 PM

The use of Cymbalta for back pain and other orthopedic pain syndromes is a huge uncontrolled psychiatric experiment. Very few patients find themselves significantly helped, from what I've seen, and many experience side effects from nightmares to thoughts of suicide to disabling fatigue. The scariest thing is that very few of them know they're taking a potent psychoactive drug -- and neither do their orthopedists, family doctors, etc. My observations come from working to help workers' comp clients. THere's been a real upsurge in prescriptions for Cympbalta, and Lyrica as well, for chronic pain resulting from orthopedic injuries. (A few years ago they were all being given Neurontin, but then Neurontin lost its patent.) One young construction worker told me simply that he'd stopped taking Cymbalta because "it just f--ed with my head too much."

I wish someone could stop this experiment. If not, I wish someone in the medical profession with brains and guts would at least study it. A large population of people without a prior psychiatric diagnosis are now taking large doses of a questionable antidepressant. If they're having problems, it's hard to write them off as products of the underlying "devastating mental illness."

Posted by: Johanna at December 22, 2007 07:12 PM

Johanna said "If they're having problems, it's hard to write them off as products of the underlying "devastating mental illness."

Unfortunately, I don't think the establishment will have any trouble at all with this. Psychiatrists have no trouble whatsoever declaring SSRI-induced mania to be a product of "underlying" bipolar disorder. Sure, it never happened *before* we treated you but that's just because we caught your bipolar disorder in a depressive cycle.

I'm sure the same rigorous, scientific reasoning will be applied to whatever these pain patients end up developing.

Posted by: Francesca Allan at December 23, 2007 05:12 PM

I was prescribed Cymbalta by my long-time (over 5 years) chronic pain practitioner. Years ago, they tried me on Neurontin and I hated it - having experiences of the sheets wrinkling under my pillow at night causing color episodes behind my eyes. I believe that is called hallucination! And I do NOT have depression. I have pain. I work 40 hours a week as a paralegal in a defense med-mal law office, am a full-time wife and mother of 3. Cymbalta did not help my pain. It did cause me to hold fluid and have weird exotic nightmarish dreams. When I tried to come off it, the trouble REALLY began. It took almost 8 weeks to get completely off and during that time I rarely slept over 45 minutes without waking up, had "twitchy" legs & arms, trouble concentrating, going to sleep while driving, constipation to the point of hospitalization and others. If I had been told of the possible problems with taking the drug, I would never have taken it. This is not a medication to be taken for pain control.

Posted by: Brenda Hocutt at January 4, 2008 11:27 AM

I'm so glad I found you guys! I've had chronic SI problems for years. I've recently been prescribed Neurontin - and it was horrible. I know they're trying to get me off opiates, but making me feel "crazy" isn't the way to go. I had heard that Cymbalta had "potential" as a pain med and was about to suggest it to my doctor instead of the Neurontin. (Just to demonstrate that I'm "cooperating.") Now, not only will I not suggest it, I will resist the suggestion if HE makes it. Thanks so much.

Posted by: vicki at February 11, 2008 03:00 PM

I've been on cymbalta for about a year now and I have to say it has helped me. It has not relieved my pain as much as a true pain reliever but has helped and has kept my depression at a livable level.I think at a higher level it would help more but I haven't asked. I took myself off it once cold turkey and had no withdrawal at all. I don't see how one person can go through withdrawal so badly and another not. I DO know what withdrawal is. Been there, done that and never want to be in that country again. But not with Cymbalta. It was, one day I was taking it, the next day i'm not. No repercussions at all.

Posted by: cynthia powell at June 1, 2008 05:26 PM

"The undersigned are calling upon Eli Lilly to provide a written detailed description of the moderate to severe withdrawal symptoms that patient's are experiencing while trying to discontinue their use of Cymbalta."

Please, sign the petition online:
http://www.ipetitions.com/petition/Cymbalta1/

For those who are not lucky enough to withdraw that easily there's a support group:

http://www.cymbaltawithdrawal.com/


Tue Apr 01, 2008 11:20 am
"Hang in there Jeff....

Its a very rough road, but as you can see from the people on here, its possible to get off this stuff successfully. Try to remember what you were like before the Cymbalta - without the rage - and know that someday you will return to that. Reassure yourself that it is the Cymbalta, and not you. I know that doesnt make it much better...but at least you know that the real you isnt this mad, angry person.

I am down to 1.8mg today - down from 60mg. The last couple days have been torture with the mood swings. I am angry, irritable, irrational, and physically want to hurt people that annoy me further. I am trying to realize this will pass and to just stay away from people. This is NOT me. Ive never been an overly calm person, but I certainly have never been this type of enraged person prior to Cymbalta Withdrawal. I am snapping at people and not tolerable to anything or anyone...including myself. I hate being this way, and I hate who I have become on this stuff. I fear how bad it will get once I get down to 0mg - which should be Friday."

"TTue Apr 01, 2008 2:02 pm
Thank you for the encouragement, I need it! Thank you also for reminding me that it is not me that is causing this rage and anger and wanting to hurt others. I am not sure what the doctor will say tomorrow but whatever it is the final word will be I am getting off this Cymbalta. I will keep logging onto this board and venting. I feel this is the only place I have to go that people understand what I am going through. My wife is supportive but does not understand, she has had medical training and even worked in a psych unit at San Francisco General, she tries to understand but doesn't. Here I know others have actually walked the walk and understand how this drug is controlling our thoughts and our actions. This could make a good sci fy movie of aliens invading us through prescription drugs, taking over the world through Cymbalta. Cymbalta spelled backwards is actually the name of an Alien planet far far away called "Atlabmyc". At least I have some sense of humor now and then."


http://www.cymbaltawithdrawal.com/viewtopic.php?f=4&t=170

Posted by: Ana at June 2, 2008 04:59 AM
Post a comment









Remember personal info?






pic1.jpg

Patient Blogs. Sites.
Doctor Blogs. Sites.
Activists. News.
Social Networking. Forums.
Science. Big Pharma. Ethics.
Current Affairs
Seattle Stuff
Smoking. Stuff.

Info
About Furious Seasons
Email
Other Articles
ZYPREXA Documents
Alt ZYPREXA Documents Source
Blakemore-Brown Transcript

 Subscribe in a reader

Recent Entries
George Carlin
Doctor Calls For Loosening Of DSM Criteria For Adult ADD
Lilly Releases Zyprexa Long-Term Injectable Data
When I'll Be Posting
Cymbalta For Knee Pain?
When Do You Read?
FDA Didn't Get Paxil Risk Documents
Feds Probing Glaxo Over Hidden Paxil Suicidality Data
Neuroscientist Slams The Bipolar Child Paradigm
Thirteen Percent Of Pregnant Moms Using Anti-Depressants
Suicide Down In 2006
Congressmen Call For End To Chantix Tests On Vets
Depression Linked To Absolutely Everything, Solutions Elusive
Paxil On Trial
Military Vets Used As Research Guinea Pigs
Recent Comments

Ana on Cymbalta Pain Treatment Claims Overstated?

cynthia powell on Cymbalta Pain Treatment Claims Overstated?

vicki on Cymbalta Pain Treatment Claims Overstated?

Brenda Hocutt on Cymbalta Pain Treatment Claims Overstated?

Francesca Allan on Cymbalta Pain Treatment Claims Overstated?

Johanna on Cymbalta Pain Treatment Claims Overstated?

Lily on Cymbalta Pain Treatment Claims Overstated?

Jane on Cymbalta Pain Treatment Claims Overstated?

truthman30 on Cymbalta Pain Treatment Claims Overstated?

Stephany on Cymbalta Pain Treatment Claims Overstated?

Archives
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
December 2007
November 2007
October 2007
September 2007
August 2007
July 2007
June 2007
May 2007
April 2007
March 2007
February 2007
January 2007
December 2006
November 2006
October 2006
September 2006
August 2006
July 2006
June 2006
May 2006
April 2006
March 2006
February 2006
January 2006
December 2005
November 2005
October 2005
September 2005
Resources
Mental Health America
National Alliance on Mental Illness
Depression and Bipolar Support Alliance
National Institute of Mental Health
McMan Web
Search


Powered by
Movable Type 3.2