November 16, 2007Seroquel XR Gets New ApprovalEarlier today, the FDA approved Seroquel XR--the extended release version of the atypical anti-psychotic Seroquel--for use as a maintenance treatment in adults with schizophrenia. What with all the new FDA approvals going on or imminent for the atypicals--Abilify for kids last week, Zyprexa on the horizon--you'd almost think there must be something magical about these drugs. But there isn't. I'm sure we are going to see some new and novel marketing campaigns for these drugs, which ought to be more novel than the drugs themselves. Posted by Philip Dawdy at November 16, 2007 10:43 AM
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extended release Seroquel? show me one patient who has been on Seroquel that actually thinks this is a good idea? I feel sorry for anyone who gets put on the XR version. It's hard enough to have a few hours out of the day, a few days a week, where you don't feel like a zombie and have a functional brain, on the immediate release version. Anyone who gets put on the XR version, cept maybe some serious cases os schizophrenia that would improve thier functioning on such a heavy dutey med, is going to end up worse off then they ever were befor.... ie they'll loose thier ability to function and loose whatever sort of life they actually had, become the perfect compliant zombie patient.... ... But I guess that is the whole point these days in psychiatry. Seems to me the whole field is set up to make sure that any and all "serious" psyche cases (BP schizo etc) stay as dissabled and disfunctional as they are, or become worse off - As long as they are sleeping all the time, not able to feel normal feelings, and not able to make a ruckuss or complain beacause they are numbed enough.. well let's call that progress and wellness. what TF ever, XR seroquel is a bad idea IMO. The only reason I realized Seroquel was having a bad effect upon my life when I got up to the 600mg dose (I am BPII without psychosis, but I had an idiot Pdoc -big suprise) was because the people in my life who cared about me kept telling me I was not myself and convinced me to lower the dose. I don't even remember a four month chunk of my life thanks to being on such a high dose. I am assuming that with teh XR version, even the lower doses will have a bad effect on many. I know for me the 600mg dose mainly caused problems because it never worse off at any point of the day or night, leaving me with no time where I could actually use my brain for deeper thought about my life etc. Well, we will see. Come 2009 or 2010, we'll see the lawsuites rolling in. If Seroquel immediate release makes a decent portion of patients go on an uncontrollable eating binge for a few hours after they take it, until the majority of those effects wear off, just immagine the weight gain, diabieties issues etc., that an extended release version is going to cause. I wonder if the Abilify folks will license Spongebob Squarepants as a spokesperson for the drug. Posted by: Puckett at November 17, 2007 05:37 AMI am using Seroquel and I think it is very effective in controlling my mania. The XR version is probably the same thing but more expensive. As long as the state pays for that, I wont be complaining. Posted by: Extrememoo at November 17, 2007 10:09 AMSeroquel XL based on my own experience would simply be an extension into a living hell. The withdrawals alone are reason enough I won't take Seroquel ever again. What a nightmare! extended release all day stupor, wow. Posted by: Stephany at November 17, 2007 03:52 PMI am an ex-opiate addict (clean for 6 1/2 years) and was taking methadone for a little while, than suboxone in combo with seroquel (300mg, once before sleep) and it has honestly been a god send...I have suffered from insomnia my whole life even before my addiction, and the seroquel does its job for the 1 purpose I use it for - sleep. I am not a bipolar or anything - always been a very happy person - done great in school - I am just another normal person, in college majoring in criminal justice...Its funny as I read this, because I happen to agree with 80% of what you have said...My DR pushed the XR on me today, gave me a sample pack of some 300mg XR, taken once before sleep...I normally take 300mg of reg. seroquel, and it knocks me out about 1-2 hours after taking it - I get great REM sleep and wake up refreshed every morning - The eating is not a problem for me I have a tall and skinny build and fast metab- My DR said try it, see if it works better and if it doesn't than just go back to Seroquel...What do you guys think, should I switch over? BTW I have tried every other rx sleep aid out there, ambien, lunesta, all of that crap and none of it works..Seroquel on the other hand, FOR SLEEP, works great for me..But thats just me... Posted by: db at November 29, 2007 06:53 PMI have been taking Seroquel 200 mg 4 x a day for a total of 800 mg a day for almost a year. I also take Lithium and Ambien to sleep. I am a rapid cycling bipolar I without psychosis. The reason I have to take 800 mg a day is because the half life of seroquel is 6 hours, and I need it to stay in my system so I don't get manic. I'm not zombied out or sleep all the time. This is the best medicine thats on the market and an XL of it would be great. I can't wait for the FDA to approve it for bipolar disorder. Also the XL isn't probably that much more expensive than the regular because I don't know about yall but without insurance my seroquel is $895 dollars a month. In 2017 there will be able for a generic to be made. I hate that Aztra Zeneca charges so much for a medicine that so many people need. Seroquel is the best med on the market for bipolar I and schizophrenia. Posted by: Brian at December 4, 2007 11:45 AMHey folks,i have to admit that seroquel has done wonders for me,at times it can make you feel flat,however,depends on when you take it,i was recently prescribed abilify,i hated it so much,that i couldn't wait for it to get out of my system,i take 3 other meds to,klonopin,tegretol,and remeron,i also take seroquel as a prn,and abilify was added by my docter becouse i kept asking her about it,it made me real depressed and i didn't want to be bothered,but i would never want to take seroquel xr,since i don't need the xr,i use it for sleep and also when my mind races to much,from anxiety.Abilify made me think of depression to much and how bad i felt,awful,just awful. Posted by: kristine at December 20, 2007 08:57 AMI made the switch from Seroquel to Seroquel XL and found the new version to be very beneficial to me in treating my psychotic disorder; the differences between the two drugs is really night and day. I was on a night dosage of regular Seroquel and felt it was too sedating for the daytime, so taking the XL has been great because I feel as if now I am experiencing the true potential of the drug since it actually relieves some of the symptoms the regular kind did not. i actually really appreciate seroquel. just 300mg. perhaps you just have to really be manic or psychotic, or it just happens to balance things for some people...sure, i'm more tired, but that's the point, i think, and it's not all day (regular) or now really at all (XR - recent). i can actually sleep for once in my life - time to behave more like a normal person, for better or for worse. abilify i tried as well, because i had doubts about having to sleep regularly at first, but it didn't work and only gave me akasthesia. back to the seroquel, and it was like instant relief. then to xr, because i did start napping afternoons and XR is like taking nothing at all side effect-wise but still effective where it needs to be. i am annoyed though that the price will be different. oh well. lol. oops - forgot to mention the addition of provigil when back on the seroquel. maybe that's why i can stay awake this time around. whatever. i'm not really manic either, but depressed, supposedly. so sue me, but i think i was having a mixed episode for undiagnosed BPI. cymbalta as well on the second try. but it seems to be working. i am more socially able and relaxed and my intellect and creativity seem unchanged. i can make rational decisions esp. regarding food. it's worth what i pay with insurance. although, that will probably change and i'll be broke. Posted by: LD at March 22, 2008 09:00 PMHi, I'm Bipolar I rapid-cycling, used to take 225-800 regular Seroquel. I am now on 300mg XR. I also take slow release Post a comment
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