September 06, 2007

When Doctors Lie About SSRIs

The New York Times today has an interview with Sanjay Gupta, a psychiatrist at the University of Buffalo not the CNN TV doctor. In his interview, Gupta asserts:

"Q. What is the current thinking on a connection between selective serotonin reuptake inhibitors, or S.S.R.I.’s, and suicide in adults?

A. In my opinion, there is no connection. It was thought many years ago that Prozac, the first S.S.R.I., could cause suicidal thinking in adults, but that was never proven."

Gupta is either a liar or he is lazy in his research. For example, earlier this year a Lilly-sponsored study of Prozac found:

"Hot off the presses is a research study asserting that 14 percent of patients in the study who did not have suicidal ideation at the beginning of the study wound up with suicidal ideation after being given 20 mgs. of Prozac. "Relatively common" in the authors' estimation. The study lasted 12 weeks and involved 414 patients, 59 of whom reported suicidal ideation during the study."

The medical literature is littered with studies like that one, and David Healy wrote an entire book, Let The Eat Prozac, which delved into the phenomenon. And SSRIstories.com is filled with accounts of suicidal behavior by patients on Prozac and the like. So what lack of proof is Gupta referring to? Or is he just waiting for an honorarium and consulting fee to speak the truth?

His answers about anti-depressants and weight gain and how people with depression are likely bipolar were funny as hell too. (Via Beyond Blue.)

How do these asshats get so much credibility with the media? Has the NYT ever published a Q&A with a patient who got screwed up by these meds?

Posted by Philip Dawdy at September 6, 2007 12:41 PM
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Comments

Wow. Yes, he is lying. All it takes is a cursory review of the available documentation. Makes you wonder what the sam hell we are dealing with here. Something profoundly depraved.

Posted by: flawedplan at September 6, 2007 01:21 PM


I just got emailed a study claiming that since anti-depressant use in teens declined, suicides increased. The emailer pointed out that even if the results are valid, antipsychotic use increased in the same time period. The definition for bipolar is so broad these days, that anyone who answers yes to the question, "have you ever been stressed out?" is at risk of being so labeled. Sanjay is a proponent of that idea I guess. The idea that all depression and all adhd are really bipolar is a huge marketing bonanza for antipsychotics.

Posted by: Sally at September 6, 2007 01:52 PM

Hello Philip,
Re: Sally's comment. I sent this to a corresponent earlier....
There's little doubt that some of these tragic deaths have been caused by sudden SSRI withdrawal. Physicians who were quick off the mark prescribing an SSRI, on the back of little proven safety and efficacy, were more than willing to not do so, once the causal suicidality risk was exposed--After all, who wants to be caught prescribing a drug that has been proved to induce thoughts of suicide, and may also activate the patient to perform the actual act of suicide.

However, even if the motive for prescribing these chemicals for everything from depression and general anxiety disorder (GAD) to an itchie bum, were noble and of the best intentions, they were ofttimes ill-informed intentions, as maybe was also the case to suddenly stop prescribing these chemicals--sudden decrease of highly elevated serotonin sometimes causes people to do the most outrageous things.

It should also be noted that during the periods mentioned in the WPost article, there has been a huge increase in the use of other psychiatric drugs.... That couldn't have been a contributing factor--Could It?!

Regards, Stu.

Posted by: Stuart Jones at September 6, 2007 02:17 PM

Dawdy--On NBC news tonight they are reporting a 76% increase in suicide in teenage girls since the warnings were taken off anti depressants in 2003---they are suggesting that more kids are killing themselves because the warning labels discouraged them from using anti depressants! WTF? By the way, please check out our Leadership 21 Blog, which is www.leadership-21.blogspot.com.

Posted by: lizzie simon at September 6, 2007 03:56 PM

jesusfrigginkrist:

To all you folks who just got spun like tops by that p.r. push today:

Decreased SSRI => Increase suicide?

Plausible? Sure.

IF PRESCRIPTIONS FOR SSRI'S DID NOT ACTUALLY INCREASE DURING THE SAME TIME PERIOD!

All the decreases in use happened after these deaths. Usage was still going up b/w 2003-04.

Last I checked, cause does not come after effect.

Ugh . . . I heard this crap on NPR and I knew that it wouldn't matter that this makes no sense. All people will remember is this crap

C'mon people. Do you enjoy being spun like this?

Posted by: Morris Berg at September 6, 2007 04:41 PM

Oh . . . and I've had a suicide prevention stand in my office building all week.

This is - in itself - noble.

But this is clearly part of a big multi-pronged PR push - national and local.

NPR, NBC, CNN = same day. It doesn't happen by itself.

Think about it, people. This type of push is how PR works. All it takes is a few doctor shills, a little astroturf, and some gullible reporters happy for a story that is already written for them and voila!

Posted by: Morris Berg at September 6, 2007 04:55 PM

Broken record here: the ONLY time I ever felt the direct compulsion to kill myself was on 40mg of Prozac, it's not the ordinary sadness, or depression, that was wicked shit. I will never forget it, either will my family! I am a regular person, with typical "problems"--on Prozac I was wildly insane, standing on the roof of my car at midnight in my town, in pouring rain screaming. I crawled into the PCP's office after that incoherent and all I could do was say these words: "You drugged me up". Took me freaking 9 months to get off that crap. That's when I learned about withdrawals that held brainzaps,etc. similar to removing Seroquel, to the point I knew to recognize what was happening to me from the Prozac nightmare.

Posted by: Stephany at September 6, 2007 10:36 PM

Dr. Gupta is a consultant for Lilly. I'm sure you're shocked. I saw him give a video CME exercise that was very dismissive of the metabolic issues Zyprexa can cause. Don't know him personally, but from the little I've seen him write/say, I know I differ with him quite a bit.

Posted by: Clin Psy at September 7, 2007 03:42 AM
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