September 18, 2007

The Zyprexa Chronicles: Zyprexa Loses Market Share

According to Decision Resources, a market tracking firm, Risperdal and Seroquel have overtaken Zyprexa as the go-to antipsychotics in treating schizophrenia. I mostly pass along this news on a for-what-it's-worth-to-ya basis. I also found this quote from the press release interesting:

"'Zyprexa dominated the schizophrenia market just two years ago; however, recent focus on the drug's risk of weight gain and diabetes has changed physician perception of this agent,' said Sandra Chow, analyst at Decision Resources. 'With the launch of new formulations and line extensions over the next two years, such as AstraZeneca's Seroquel XR, Wyeth/Solvay Pharmaceutical's bifeprunox, Janssen's paliperidone depot, and Eli Lilly's olanzapine depot, as well as the expiration of Janssen's Risperdal patent protection in 2008, the landscape of schizophrenia is poised for even greater changes.'"

I guess doctors do read the New York Times and blogs after all. I'm kidding, of course.

But, seriously, what the analyst avoids saying is exactly what the schizophrenia market will chance into. Methinks, there is going to be even more bad news on that front and likely around Risperdal and Seroquel. Both the drugs and their makers are the objects of several lawsuits (one a class action), a Congressional investigation and I imagine the various states are poking as hard on how these drugs were marketed and sold to their state Medicaid programs as they are on Zyprexa. We just don't have the Risperdal or Seroquel documents in the public's hands.

Yet.

Posted by Philip Dawdy at September 18, 2007 12:03 AM
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What about the British studies that found that cheap Haldol was just as effective(?) as any of them? Anything that sedates people will appear effective. Everyone has a theory, This is mine.

Posted by: Mad Crone at September 18, 2007 06:00 AM

I am eternally grateful that Zyprexa is losing market share. A heck of a lot of people worked to make this happen, despite the FDA's complete ignoring of this lethal drug; despite the evidence loud and clear in their internal documents
that revealed that the company knew it could cause diabetes, hyperglycemia, and death. But I would say to Western Europe, look out. Lilly is making a big push there to make up its loss of market share here. The same thing will happen.

Just five years ago, my only son demonstrated some odd symptoms. Two days later, while the "snipers" were driving all around the hospital where he was taken, he fell into a coma, never to come out. He died on October 5, 2002, at the age of 39, of profound hyperglycemia from Zyprexa. A wonderful human being, he had managed well on lithium for years, finished college and got a Master's at Cornell. But when he went onto Maryland Medicaid, he was pushed onto Zyprexa. I believe that bribery got the drug on Medicaid's formulary in Maryland and many other states, and I hope that all fifty, as opposed to the current ten states, will sue Lilly.

To all those at Lilly assigned to monitor Furious Seasons, I ask you if your paycheck is worth making instruments of death. And to the decision makers in Washington, who glide by all the deaths; all the members of Congress and the FDA who could be doing something, I ask you if your jobs are worth the bribes that you get from Pharma that result in so much death.

And in memory of my beloved son, I would like to suggest that the answer to these questions is "no".

Posted by: Grieving at September 19, 2007 11:46 AM

In my opinion, Haldol was the worst drug ever developed. I always make a point of claiming to be allergic to it. It might have been cheap, but it was a nightmare. I also find Lithium to be extremely over-rated and also inexpensive.

As I keep harping on about, statistics and studies aren't terribly effective when it comes to doing what's right for any particular patient. We need patient-based, rather than evidence-based, medicine. I'm taking Seroquel "off-label" (as a sedative), as little as I can get away with, and it seems to be working reasonably well. 100% of the people in this study are doing okay, for now. That's all I know.

Posted by: Francesca Allan at September 19, 2007 04:09 PM

Then there's orthomolecular psychiatry...

Posted by: kynos at September 25, 2007 08:16 AM
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