September 14, 2007

Sally Satel On DSM-V

Sally Satel, a Washington D.C. psychiatrist and conservative policy wonk on mental health issues, had an op-ed in yesterday's New York Times. It's hard to tell what drove the paper to run an op-ed on the DSM right now. All the same, DSM-V is very much in the planning stages--it's due sometime in 2011--and there is a lot of controversy within the psych world over some diagnoses, especially early-onset bipolar disorder. Satel, who also writes for the Weekly Standard from time to time, takes up the bp kids business first:

"High on the agenda will be the controversial diagnosis of childhood bipolar disorder. Recent data show that office visits by children and adolescents treated for the condition jumped 40-fold from 1994 to 2003. We still don’t know how much of this increase represents long-overdue care of mentally ill youth and how much comes from facile labeling of youngsters who are merely irritable and moody.

"Part of the confusion stems from the lack of a discrete definition of juvenile bipolar illness in the diagnostic manual. But there is a deeper problem: despite the great progress being made in neuroscience, we still don’t have a clear picture of the brain mechanisms underlying bipolar illness--or most other mental illnesses."

I've been in the mental health world for almost 20 years and it is discouraging to me that doctors are still saying much the same things now that they were about the sources of mental illnesses back when--namely, that it's all driven by chemicals in the brain and we'll identify the central lesion through MRIs and PET scans any day now. It's 20 years later and there is still no concrete answer as to what is going on in peoples' brains. After a generation of waiting for "proof," I've lost my patience. When the docs can establish the root cause of bipolar disorder in children, for example, then I'll be a lot more sympathetic to listening to wonks talk about diagnostic criteria and treatments, especially when it comes to applying adult disorders to children.

Satel offers the usual explanation--the brain is very complex!--and moves onto the DSM and depression.

"Another may be what Dr. First calls the “unfortunate rigidity” that all-or-nothing diagnostic checklists and sharply bounded categories impose. In order for the condition of a patient to meet the definition of clinical depression, for example, he or she must have five out of nine symptoms. But does a patient with only four symptoms have a different disorder, or no disorder at all?"

I'm not quite sure I buy that there's that much diagnostic rigidity in the DSM-IV, aside from what insurance companies require or the official rigor of clinical trials. Satel offers no evidence that this situation is much of a problem.

But she has a solution.

"One way to improve the classification of mental illnesses would be to define certain pathologies along a continuum so that patients who are truly ill won’t fall short of qualifying for a diagnosis. Take major depression. The symptoms could be weighted so that suicidal preoccupation or immobilization, the most extreme and debilitating aspects, would get high scores, while loss of energy and interest for a short periods would get lower scores. Thus, a patient with few, but severe, symptoms would not be excluded.

"A more nuanced approach could also make a real difference for population surveys of mental illness and clinical trials, both of which tend to rely on rigid symptom checklists."

That's an interesting idea, but ultimately I don't think it would change much in practical terms. I cannot think of ever hearing of anything other than a few stray instances of a patient going to see a doctor, telling the doctor that they are suicidally ideating and unable to leave the house, say, and not have that patient walk away with a diagnosis of depression because they happened to be sleeping well and eating well at the same time. As these things go, depression is easy to diagnose, and schizophrenia is a bit harder although it's obvious much of the time (I've dealt with enough street folks over the years to say this). Bipolar disorder and ADHD are much trickier.

There has been much noise lately about whether depression is over or under diagnosed, and the World Health Organization and its allies last week launched a huge media push to convince the world that depression is tied to every ailment under the sun and that depression is under-diagnosed. It's hard to say who is right on this matter absent an objective standard, but whether over or under diagnosed, I am not sure that we have much better treatments for depression than we did 20 years ago. And some of the treatments we have can cause very serious problems--and I can say that with the same confidence that researchers assert that mental illnesses are the result of bad brain chemistry. So we are rushing to diagnose even more people and offer them even more problematic treatments for what reason?

To be clear, where someone is suicidal or practicing extreme isolation, then I am certain a diagnosis should be made. I'm not so certain of where the diagnosis and treatments will lead a particular person.

What I find amusing is that the Times' editorial pages chose to run an op-ed from Satel. She is very much a member of the forced outpatient commitment crowd--who all seem to be in the D.C. area for some reason--but at the same time is also the author of One Nation Under Therapy, a book examining the notion that talk therapy has damaged America's character. Interestingly, you never hear much from Satel about how medications have damaged America's bodies. And you won't read it on the editorial pages of the Times either, which seems to be run by a very hidebound bunch on medical matters (the news side of the paper is different). Satel is also in the forefront of the debate over tightening--or is it loosening?--commitment laws. I have written about her work previously. And yet here she seems to be arguing for more diagnosis and more treatment. Like I said, an odd choice and one I don't trust as much of an authority.

As for her proposal that mental illnesses be regarded as existing on a spectrum, that sounds to me like yet another call for softening diagnostic criteria a la subthreshold bipolar disorder. I am against that. I've watched the practical impact of an already softened bipolar disorder--bipolar 2--lead to too many patients getting screwed up on Seroquel, Risperdal and Zyprexa. But, then, I was one of those patients, so I am biased.

Also, I find it odd that, given the lack of objective diagnostic tests, that researchers and opinionators such as Satel don't also call for the DSM-V to include some kind of guidance for doctors on re-evaluating a patient's diagnosis every so often, especially with patients who are treatment compliant and making decent progress. I think there's plenty of evidence that the course of mental illnesses can abate over time and it makes sense that some recognition of that fact be carved into the DSM as well.

Posted by Philip Dawdy at September 14, 2007 12:05 AM
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Here's the nutshell version of Satel's editorial: No one agrees on what constitutes any one mental illness. We all agree there is no discrete set of symptoms of any psychaitric disorder. We all agree no measurable physical difference between people labeled as mentally ill and people not so labeled has been discovered though I admit I think there is one, so lets keep labeling and force medication on all people anyone things might meet some of the varying symptoms anyone might call mental illness.

She not only admits no one has found proof that the cause of mental illness is not bad parenting, she goes on to say that the symptoms of mental illness haven't been identified.

Posted by: Sally at September 14, 2007 07:10 AM

Also, I find it odd that, given the lack of objective diagnostic tests, that researchers and opinionators such as Satel don't also call for the DSM-V to include some kind of guidance for doctors on re-evaluating a patient's diagnosis every so often, especially with patients who are treatment compliant and making decent progress. I think there's plenty of evidence that the course of mental illnesses can abate over time and it makes sense that some recognition of that fact be carved into the DSM as well.

Philip, didn't you know? Once mentally ill always mentally ill and the pharmaceutical companies wouldn't have it any other way.

And Sally Satel and TAC wouldn't dare risk letting any of us potentially dangerous folk off drugs to go wreak havoc. The prejudiced powers that be who put us all in boxes for power and or profit will do all in their capacity to keep us mentally ill, on drugs and in our places.

It's you and me that have to change that, not opinionators like Miss Sally.

Posted by: Gianna at September 14, 2007 10:45 AM

Excuse me while I choke myself.[just kidding]BUT--if one more doctor/psychiatrist tells me "complex" again--just this last week, I had this discussion,[with a psych] it regarded the new DSM coming out and "how it's going to be changing how all doctors diagnose people, and whatever we call her[my daughter]today, will change in 5 years." "It's complex." Okay for 2 years THAT has been the basic diagnosis. Complex.

Easy way out--this just means that "we still don't have a fucking clue, here's the medication paradigm we work with, and after that, no one knows what to do."

Posted by: Stephany at September 14, 2007 11:30 AM

Oh, and btw my daughter's brain has $6,000 worth of MRI's completed in 3-D version, and let's just begin a discussion on how Neurologists and Psychiatrists consider their fields different, and do not discuss brains together. Hmmm. I think Pharmaceutical companies think about this shit in a more cohesive way: they get their goal accomplished, as a TEAM. Maybe doctors should start thinking that way.

Posted by: Stephany at September 14, 2007 11:33 AM

I don't know where to start...once you have a diagnosis its considered to always be there, its not in the psychiatrist/psychologist framework to consider that major depression or any other diagnosis goes away once present, it may be treated into remission but its always there...
its true that a change in the DSM often does little to change the current practice of psychologists, but for those in training, it can mean an entirely new way of viewing mental illness, for better or worse. I agree with Satel that the DSM is too rigid, but not exactly in the way she sees it. The DSM is too all-or-nothing, either you have the diagnosis or not, which leads to overdiagnosis, if there were more of a continuum there could be room to look at individuals in a more holistic, less label driven way. All this makes me wonder, have you reviewed the PDM, and if so, do you have any thoughts?

Posted by: Abby at September 14, 2007 12:43 PM

What needs to be carved into the DSM is some recognition that people have lives and that lives affect mood. This seems to have been completely thrown out the window in this effort to mold mental illness into a brain disease and create a medical model for psychiatry. Doctors like Sally Satel have (in my view) completely lost perspective on what makes people suffer and we need some heavy duty backlash against the DSM to stop this nonsense.

Posted by: Sara at September 14, 2007 02:53 PM

I can't figure Sally Satel out. Initially, I wrote her off as an E. Fuller Torrey think-alike. Then I read her being tough on disability cheque cheats and got more interested. Then I read her blathering on about a high profile murder-suicide and so I turned her off again.

Satel's words quoted here (no, I didn't bother to read the whole op-ed piece) seem pretty middle of the road. (Really not meaning to pick a fight. This is just an ambivalent comment from an ambivalent contributor to this forum.)

For what it's worth, I believe there are many paths to mental illness and one of them is likely loopy brain chemicals. That wasn't my path so I'm not much interested in people who insist that it was.

I'm more interested in the current research into neuroplasticity (how the brain changes in response to injury/illness). It would be nice if the answer came in my lifetime but, at 41, I'm not holding my breath. Still, I believe the answer lies in neurology, not psychiatry. One's a science; one's witchcraft.

Lastly, and on a radically different note, is there anyone here who wants to be hired as an editor on a one-time basis? My usual editor is unavailable and I'm at draft #2 of a moderately interesting essay on voluntary vs. involuntary treatment for bipolars. If anyone's interested, please email me at efallan at canada dot com.

Posted by: Francesca Allan at September 15, 2007 07:29 PM

Perspective is everything, really. http://www.breadnroses.ca is my sometimes hang-out. There, I might be considered a reactionary. (I just told them over there that I could pass for a moderate over here.)

Posted by: Francesca Allan at September 15, 2007 10:03 PM

Yes, it is certainly true that life circumstances alone do not account for all aspects of mental illness and I realize I've been pushing that side of things pretty hard -- more as a devil's advocate than anything but I still think leaving that out of the loop in determining solutions is for the birds really. There's a patient's life and how he tells his story, genetic predisposition (for handling stress for instance) and finally social ills. It's a complex business and the DSM for all its many pages and disorders attempts to simplify something that can't be reduced so easily to formulas.

Posted by: Sara at September 16, 2007 08:27 AM

I can't stand the DSM...so stringent and when physicians rely solely upon that and just throw people into little boxes based upon a checklist, it drives me mad.

It almost seems that either the doctors are incompetent, lazy or both.

Well, a lot of them are.

Signed,
Tired and cranky PA

Posted by: patientanonymous at September 16, 2007 02:52 PM

Francesca, the problem with the "loopy brain chemical" theory is that it dehumanizes people, and, of course, also, no one can prove it. I have no doubt that people are born with somewhat different personalities. The individual variations in human personality are a delight, and yet, mental illness must always be caused by something. As the guy somewhere out there in cyberspace wrote, to blame the brain for mental illness, is like blaming the bat for a home run. Telling people the personality traits they were born with are defective is horrific. Allowing people to change those traits if they want to, humane.

Posted by: Sally at September 17, 2007 06:18 AM

Sally, with respect, I disagree. Why would loopy brain chemicals (bipolar) be any more dehumanizing than a defective pancreas (diabetes)? It's not a moral judgment -- it's a possible reason for emotional distress.

You're right that the chemical balance theory hasn't been proved. Neither have any of the many other theories on the causes of mental illness: closed head injury; crazy-making people; sexual abuse; toxic environment; lack of sunlight ....

I try to steer away from statistics and studies (so-called evidence-based medicine) towards patient-based medicine. Anecdotally (a dirty word in the science world), I have found that closed head injuries cause mania. In me. Electroshock, car accident, drinking too much and falling down all appear to have had the same effect. On me.

Except for those manic episodes, I would be diagnosed with unipolar depression. Again, merely anecdotally, I have found that my downs tend to come in October. I've also found that I need to get a good night's sleep or I fall apart very, very quickly. I also have to watch what I eat, e.g. aspartame and monosodium glutamate make me feel horrible. I regularly get what I call the "proteinateous" shakes where I get weak, dizzy and need cheese or milk or some other source of protein to recover. I need lots of physical exercise. I need a room of my own. I need to keep my drinking down to a dull roar.

I found a drug which seems to work for me -- Seroquel. I've done the risk/benefit analysis and decided to go with it. I know it's an atypical anti-psychotic but I use it as a sedative. I use it reactively, taking it only when I feel like screaming. I was given 2 weeks' worth, to be taken 25 mg in the morning and 600 mg at bedtime. I can't afford to go through them that quickly, so I'm taking 200 or 300 mg a day, taken whenever.

I have no follow-up arranged and no doctor lined up to check on me. I'm just flying solo and doing the best I can. Aren't we all? That's why I love this blog -- it's a place to trade unbiased information. I live in Canada, home of the world's best health system (just ask Michael Moore), yet medical science failed me.

It's my belief that Seroquel is saving my life. Could be the placebo effect, could be my neurochemicals rebalancing, could be aliens, could be anything at all. I really don't give a shit WHY I feel better but I certainly revel in the fact that I DO feel better.

These are nuggets of wisdom I've picked up over my 20 years as a mental patient. Use them if you want. Ignore them if you want. But understand that, in the debate, I'm on your side, not theirs.

Posted by: Sally at September 17, 2007 07:46 PM

"Sally," you literally took the words right out of my mouth. :)

Posted by: Francesca Allan at September 18, 2007 05:09 AM

In response to the above post (written I think not by another Sally but by Francesca), the loopy brain chemicals theory dehumanizes people by telling them their perceptions are invalid. I agree that we are on the same side. I think its important to understand how terrible the defective brain theory really is.

If you argue that because I was born with a different personality than you, I get upset when exposed to stress more quickly, or become unhappy sooner and stay that way longer, I'm fine with that. It's when you argue that these differences in humans mean that one is superior to another that I have problems. If I am less tolerant of stress than you, there's a place for me in stopping stress, and if you are more tolerant, you might be better in a stressful job than me. As for mania, it is crucial when someone is manic that the underlying causes of the mania be understood, that the person not be written of as "crazy, brain defective," as has been proven by all research which all indicates that at the very least people labeled as bipolar respond better to talk therapy than to drugs, or at the very least, even in biased big pharma studies, need therapy in conjunction with drugs.

Like mental illness, diabetes usually has a strong environmental component, to say it doesn't would be a mistake.

And tangentally, I don't care what anybody says, if a 10 year old commits suicide, she's been abused by somebody. A ten year old doesn't commit suicide because of a spontaneously defective brain.

I would argue that all of the other potential causes of mental illness you mention are proven, i.e. "closed head injury, crazy-making people, sexual abuse, toxic environment, lack of sunlight." To say emotional distress is caused by the brain and nothing else is to say that someone who experiences emotional distress caused by the brain and nothing else must be controlled and segregated because we don't know what they might do, thus dehumanizing the person, when in fact one could say that we don't know what any human might do and thus the person labeled as having a defective brain is not really defective or sub human.

Posted by: Sally at September 18, 2007 06:03 AM

Hi, Sally. Yeah, that was me. We're preaching to the choir with these dialogues and we've got some bad miscommunication going on.

I feel misunderstood -- I only suggested that loopy brain chemicals were ONE of MANY paths to mental illness. It's hard to PROVE what path caused which mental illness. Indeed, my own path seems to have had nothing to do with brain chemicals (save as the correlate, not as the cause) and everything to do with closed head injuries. I can't PROVE it, just as they can't DISPROVE it. I can only go with what seems to be the case, based on 20 years' experience.

Update: I just touched base with my local mental health centre (crisis line upon to 5:00 p.m. every day!). There's a three-week waitlist for a shrink. Last Monday, I was released "against medical advice" and given a two-week supply of drugs. (Slight temporal problem, there, methinks.)

The intake counsellor suggested a walk-in clinic. (Yeah, I'll just saunter in to a walk-in clinic and ask for Lithium and Seroquel. No questions asked. No problem.)

(Sarcasm, in case I'm not getting my point across. It's my ultimate answer to absurdity.)

Posted by: Francesca Allan at September 18, 2007 04:38 PM

Francesca, I get a little defensive (okay more than a little, maybe hysterical) about the brain chemical thing. Sorry. Good luck with your meds, be safe.

Posted by: Sally at September 18, 2007 06:20 PM

Don't be sorry, Sally, because you make excellent points and give me yet another point of view to ponder. I kind of feel one step removed from the whole debate: just show me the evidence and I'll make up my mind, without thinking any one theory has any more claim to fame than any other.

To be honest with you, the neurotransmitter theory seems the most blameless, from a patient's point of view, and I kind of admire people that believe it. Their resolve tends to fall apart in a discussion, though. Just ask them which neurotransmitter is to blame or what they think about down-regulation or neurovascular coupling and whether they've read Grace Jackson or Eliot Valenstein, and they tend to get sketchier on their theory.

A couple of issues ago, in Harper's, there was a great article by Gary Greenberg called "Manufacturing Depression" which is certainly worth a read. Greenberg participated in a drug trial and had lots to say on the experience.

I was relieved to hear (from the intake nurse) that Seroquel "couldn't be abused." That's good (but demonstrably false) news because it means a walk-in clinic might be more forthcoming. She sounded nice and worth meeting. I used to have a case manager whom I quite liked and she came to visit me wherever I was living. It's better than being inside, I guess.

Posted by: Francesca Allan at September 18, 2007 08:01 PM

Francesca, I read the Greenberg article. It was a breath of fresh air. As an abused child whose parents wanted me to be crazy for years, I find the neurotransmitter theory offensive because it allows abusive nuts like my parents to dramatically claim that I was born crazy and because of this they suffer,(my "diagnoses": dysthemia and generalized anxiety disorder both in remission). My disagreement with the neurotransmitter theory doesn't mean I think all mental distress is caused by parental abuse by any means. I think it may be that because of the horrors I've suffered from my family's attempts to have me labeled bipolar, I'm unable to consider how the neurotransmitter theory can be helpful to anyone.

Posted by: Sally at September 19, 2007 05:31 AM

I'm chiming in here where I don't belong---but when I saw the "Seroquel can't be abused" part I had to add Legally Bombed which has links from Furious Seasons and bpchicks discussing snorting Seroquel. I met a woman who uses meth and she told me she would rather use meth than Seroquel.

Posted by: Stephany at September 19, 2007 10:24 AM

Sally, I totally understand your point of view now. My parents weren't abusive but they were indeed crazy-makers. I don't know your situation but I do believe that, generally speaking, mental patients should give their original families a wide berth.

Louis Wynne ("Healing the Hurting Soul") said, basically, that in order to get a mental patient, you have to start with a black sheep. To get a black sheep, you have to get someone to be financially dependent and acting oddly. Somebody is benefitting from this dysfunction. My advice, not that you asked, is to find out who is driving this and then cut them loose.

Stephany, your post doesn't totally surprise me. You can snort vodka if you want a faster effect. I don't happen to like snorting as a delivery method but I'll mention it to my druggie friends as I could use the money. (Kidding. Sort of.) I've also got a cache of Lithium that I'm saving for an art project.

Posted by: Francesca Allan at September 19, 2007 04:31 PM

Unfortunately, I think that the author is yet another BP person in denial about her illness. Saying that the medications had lots of horrible side effects is a very common excuse for someone like this to use. The denial will probably go on and on unless peole like this are ever able to face up to the truth and take on the work of getting better. If I sound judgmental, well, I am. My mother is a lifelong BPI who destroyed her own life and devastated the lives of those around her because she would never admit she was sick, and would never take meds. *I* am BP-NOS, and hell will FREEZE OVER before I ever stop taking medications, self-adjust, or fool myself into thinking that "I don't need them." Acceptance of reality and a refusal to stay in denial CAN HAPPEN! They're very hard. But I'm really kind of all out of patience with this. If I can do it, lady, so can you. Get off your butt, take responsibility for your life, and quit making excuses.

Posted by: Cathy D. at August 12, 2008 10:04 AM
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