July 17, 2007

Was It The Meds or Me?

Marissa from depression introspection posed the following to me in comments following a post of mine yesterday:

"Maybe it's possible for some people that as they get older, their symptoms become few and far between. So did any of the meds REALLY help you then? :)"

It's a good question, an essential one, but I don't really know the answer. Maybe the best way to address this is to list each med I've taken and offer some of my experiences on it and readers can tell me what they think helped and didn't help.

1. Lithium: 1989 to 1997. Worked fine on manic/hypomanic symptoms most of the time. Made me fat as hell on higher doses--I hit 235 pounds at one point and I am six-foot-one--but it was loseable weight and I eventually got back down to 195. Made my hands shake and tore up my stomach. Eventually washed out.

2. Prozac: 1990 to 1993. I began taking Prozac weeks before the infamous Newsweek cover of the pill came out in the Spring of 1990. Initially, Prozac felt like the greatest medical technology I had ever encountered. I felt "better than good. The depression came back and my doc at the time, unaware of the problems swirling around the drug, began upping my doses to 80 mgs. a day. I experienced severe akathesia--although I didn't know what it was or that I should tell my doc--and suicidality. I was so scrambled on this drug that I was unable to do my accounting job.

3. Tegretol: 1993. It did nothing for me good or bad.

4. Paxil: 1993 to 1994. This was my replacement for Prozac. Since these were still pretty pre-Net days, I had no idea of the problems with this med either. It didn't do squat for depression and, again, I had problems with akathesia and suicidality on higher doses.

5. Zoloft: 1994 to early 1995. This drug just made me feel stony. And cleansed in a weird way. I got off it when I lost my health insurance. By now, I was on Lithium only and, living in San Diego at the time, was going across into Tijuana to buy it cheap--scared each time that I crossed the border that I would have to explain the bag of pills to US Customs.

6. Depakote: 1997 to 2004. Like Lithium, good for manic/hypomanic stuff but kind of rough on my body. I didn't put on too much weight from the drug. It galled me that I was taking a drug made by Abbott Labs, which had fired me in 1988.

7. Luvox: 1997. I literally took this drug for two days before stopping it. I was so agitated that I feared another Paxil go-round.

8. Ativan: 1997 to present. I've taken this drug very intermittently, a day or two every once in while when it makes sense. Apparently, it's highly addictive and you cannot take it long-term, and I never have. Good dope though.

9. Xanax: No particular year. I've been given this by friends, not docs, a few times. It makes me sleep like a log.

10. Wellbutrin: 1998 to 2004 over three separate trials. A benign, ineffective med which likely agitated the hell out of me.

11. Risperdal: 2000 to 2003. Initially, a good med that seemed to really make me focus. Also calmed the Bad-butrin agitation. This was the first of the atypicals I had pushed on me for long-term, every day use. Over time, it made me sleep a lot, packed on the pounds, made my heart take on odd beats and puffed up my face. Garbage as a long-term drug.

12. Lexapro: 2002 to 2004. Not a particularly strong anti-depressant. Gave me cracking headaches and lightning bolts in the head when I went off it. When I went back on it briefly, it made my heart race and gave me akathesia. I went off it immediately.

13. Seroquel: 2004 to 2005. My thoughts on Seroquel are already well-known. It's an OK drug for very short-term use rather as first-generation antipsychotics used to be used with bipolar. For anything else, this drug is very bad. I was in a constant fog and it made me fat as hell. In addition, it gave me horrific nightmares--such as I had never experienced before or since--and made my muscles tighten. Also, puffed up my face. I would still use it in a short-term emergency, however, should the need arise.

14. Lamictal: 2004 to 2007. Pretty good at addressing both manic/hypomanic symptoms and depression. Not perfect at it, however. Almost zero side effects on this drug.

15. Mellaril: no particular year. In the 1990s, docs used to still hand this out as a get to sleep drug. You'd take it for a couple of days and stop it. While on it, you slept like a drugged log and were impotent. Nasty stuff.

16. Celexa: no particular year. I took it for a short time twice and it did nothing for me or to me.

17. Geodon: 2005. I took this for three weeks in 2005. Caused akathesia worse than any SSRI. Lost weight on it though!

I am missing a med here, since the last time I did a hard count of what I've taken over the last 18 years, I got to 18 drugs. I'll figure that out another day.

So what do you all think worked? Me or the meds?

I have my hunches.

Posted by Philip Dawdy at July 17, 2007 12:05 AM
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Comments

My understanding of Wellness, is the idea for your doc to get you off as many meds and to have you living on the littlest dosage possible. I see a lot of people in my DBSA group come in on 5 or meds and after a few months they are weaned down to one or two.

I myself have been on only lithium since middle 2003.

It could be the meds are working and you have the right cocktail, finally after a life time of trying, or it could be that your life has reached some kind of equilibrium, and you no longer need a cocktail to make it. I hope that is the case both for you, and all your readers ho find you to be an inspiration to us.

Posted by: susan at July 17, 2007 01:34 AM

What happened to cause you to get on meds in the first place is one question that comes to mind.

I believe it is you that made it work, through self-discovery and awareness into managing life, moods, etc.to get off of them.

Posted by: Stephany at July 17, 2007 04:18 AM

oh---who knows--I can't tell with the info you gave us what exactly your story is with the drugs. My instinct, though it may be biased, is that the drugs don't do a whole hell of a lot.

My neurologist told me once that an episode has a life of it's own whether medicated or not. And that drugs often confuse the picture by adding symptoms.

I know my story (trialed and took 37 drugs in 20 years) involves drugs spinning me out and causing me to take more drugs. (this I know in retrospect--while living it it was unclear to me) I'm now off the majority of my meds--but still withdrawing--(my blog is that journey for those of you that don't know.)

I just want you to know you are one more inspiration for me. I now am aware of hundreds and networked with thousands of people either recovered or withdrawing and in the process of recovery.

Congrats again! I believe we heal everyday. I am angry at the doctor who yelled at me 22 years ago, "You need to face it--you have a disease and you will be sick for the rest of your life!" He scared the shit out of me and convinced me--even though he had poor evidence for this conclusion--my mania was drug induced. The psychiatric drugs added on continued the downward spiral.

Yes we heal and recover!

Sorry for the rambling quality of this comment.

Posted by: Gianna at July 17, 2007 04:28 AM

I also have something to say about this here.

Posted by: Stephany at July 17, 2007 05:43 AM

Thanks for addressing that. I didn't think you'd actually respond. Makes me wish I'd never used the smiley. Bleh.

Also, I'm glad that you chronicled your history with the medication. I think it gives people a resource to refer to. While medications do different things for different people, documenting your experience with all those different drugs will keep others informed about the possible effects.

Posted by: Marissa Miller at July 17, 2007 06:50 AM

Was Ambien (or another hypnotic) the drug you may have forgotten? That would be amusing since amnesia is a side effect! In any case, regarding what you call yourself from now on, I've got the word for it -- lucky. You are one fortunate fellow to get off this stuff and still be writing and thinking as clearly as you do. And in response to Marissa it does seem that people do get better as they get older (if given the chance!). Think John Nash here. Maybe it does have something to do with hormones or other body/brain chemistry that just starts to wind down or maybe we just begin to understand and accept the world for what it is and come to some peace with our environment.

Posted by: Sara at July 17, 2007 07:58 AM

Interesting history. Makes me me want to do mine but it would be longer! The funny thing about meds is that they really hit everyone differently. As far as the ADs, a lot of people that are Bipolar simply can not take them at all, me being one. They completely destabilize me. Now that may or may not have been the case with you but you certainly had some bad side effects.

I don't agree with the Atypicals as first line treatment for Bipolar. They *might* play a role for other issues like a sleep adjunct if someone doesn't want to give you a benzo or a hypnotic but generally I don't think they'll do squat for controlling any (hypo)mania. And they probably won't do much for your any depression. They can calm you down if you're really flipping out but usually only as a temporary measure and again, it depends on your brain and the med. I'm on Seroquel as an adjunct for sleep and it does nothing for anxiety (see my comment on Zyprexa to follow.)

Traditionally, yes Lithium which is the only "true" mood stabilizer or ACs. They all have pros/cons...again, every one can be (s)hit or miss.

You won't pry my Topamax out of my cold, semi-dead hand as it works best for ultradian cycling--which I have. It hits your Temporal Lobe hard so it's truly a hit or miss drug--but if it works, it can work well. Also, it's probably doing triple duty for my seizures and migraines as well. Since I just had another flip out I'm now on Lamictal too. Mood improving...

I've always likened Benzos to a decent pair of shoes--you just have to find the right fit. I've never had any "addiction" problems as they don't make me feel high or anything. They just calmed me down. Oh and a stint on Zyprexa when the benzos didn't cut it but that was brief. It worked and knocked me out like a sledgehammer hit me. My Seroquel and Imovane don't quite do that and yes...I haven't slept properly in...oh how long...chronic insomniac here.

Oh, blah, blah, blah...there's so much more I could say but I'll leave it at that.

Bottom line, meds are so individual for everyone and their brain. Some work for some, some never work for anyone.

I have a friend dx'd with Depression and ADD and finally he just said to hell with it and he seems to be managing without any pharmaceuticals. Great! I say good for him!

Posted by: patientanonymous at July 17, 2007 05:13 PM

Actually one of the lovely things my doctors always told me was that bipolar disorder gets worse with age--that I could expect deterioration over time. I've heard this from a number of doctors. More of their classic bullshit.

Maybe they're not saying that as much anymore, I don't know. I have a nice doctor now that believes in my recovery.

Posted by: Gianna at July 17, 2007 05:21 PM

The thing with bipolar "burning out with age" probably has a lot to do with being older and wiser, not giving a shit about the little stuff anymore and feeling more confident in our quirky skin.

Posted by: Stephany at July 17, 2007 06:44 PM

You know I never really thought about it till now (thanks for the post and comments) but it does seem that all the older Bipolars I know tell stories of how out of control they were when they were young, the meds they tried, and yet now they don't even need meds at all.
They are just like "fewy on the meds, they never helped for very long anyways".


Maybe it is a bunch of BS that BP gets worse as you get older and it goes untreated. hmmmm, I guess the pharamcuetical industry does have a lot of sway over science. Perhaps this idea is just industry propaganda. You should look into it. Maybe with really bad BPI you are screwed and doomed to get worse with time, but is that he case with all the rest of us beepers? Where's the data on that?

As far as meds helping, hurting or not doing diddly squat goes, I think it just depends on the person, the phase of thier illness and whether or not they get the "right med". They can save your life, but they can also make things worse. And Pdocs rarely even believe you when you say a med seems to be making you feel worse. Thier usual response is "the med could NEVER do that. It is just a coincidence". And then they continue to give you more of the same until you have a complete meltdown and they can no longer chalk it up to your being too crazy to know the difference between med induced states and the normal course of your BP.

My experience is that 85% of the meds I've tried made things worse, either immediatly or over the course of months, OR did nothing.
The other 15% have helped me short term to end mixed episodes, but long term decreased my quality of life (my ability to function well).
So, I am not really gung ho about meds being the main solution to my problems. In fact as far as antidepressants go I think they are worthless crap. I have tried all sorts, and in the end it was AMINO ACID SUPPLEMENTS THAT HELPED!!! immagine that. something OTC and cheap that I can take as needed and get immediate (overnight to a three or four days) relief from.

Sometimes I really wonder how much better off us milder cases of BP etc., might be if we were first directed to try and use lifestyle management, and nutritional methods.

I am absolutely certain that if I had been directed to try certain amino acids FIRST instead of given ADs over and over for years to treat my depression I would be A LOT better off. All the ADs ever did was make me worse. And all the amino acids do is actually work! with no side effects!

So in short - you're not alone in your experience. Sometimes psyche meds are just crap. Yeah they can help, but it is so hit and miss it's no wonder why so many people are "non-complient".

Posted by: katie at July 18, 2007 12:16 PM
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