May 03, 2007

FDA Adds Suicidality Warning to Anti-Depressants

Long in the consideration phase, the FDA yesterday ordered drug makers to amend current black box warnings to include language that the drugs may cause suicidal thinking in young adults up to 24 years of age, no suicidality in adults, and a decrease in suicidal thinking in seniors. I'm pleased that the FDA has taken this step, but am a bit incredulous at the idea that an SSRI, say, can produce suicidal thinking in you when you are 24 but not when you are 25.

Anyhow, the warning doesn't just apply to SSRIs/SNRIs, but to anything approved for treating depression including MAOIs and Seroquel.

Posted by Philip Dawdy at May 3, 2007 09:49 AM
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Happy to finally see this happen. For so long I have heard very influential people complain about the "lack of evidence" surrounding SSRIs and suicidality. They point out that users of anti-depressants are more likely to be suicidal ANYWAY, and that accounts for the greater number of individuals experiencing suicidal "gestures" and ideation. They need to look at the TYPE of suicidal gestures one sees on SSRIs: severe, violent, extreme behavior turned against oneself.

Not to mention the fact that SSRIs are now approved to treat everything from irritable bowel syndrome to insomnia to social anxiety to bad PMS to separation anxiety in dogs- and one sees the same adverse reactions, bizarre behavior and suicidality in those populations. I have never heard of someone killing themselves because of PMS. Homocide perhaps, but not suicide.

Once again, I am glad the FDA has made the right decision. Too bad it is too late for so many. Too bad I never knew.

Posted by: lily at May 3, 2007 02:05 PM

With the extension of age to 24 and applying the warning to all antidepressants, plus so much more exposure in the media, how much less likely will someone get proper treatment over liability concerns on the part of the physician?

If this meant more people are referred to qualified psychiatrists rather than being treated by their GP then fine.

But we all know the accessibility of psychiatrists to the general population.

It's legal concerns overriding proper treatment of people with mental illness. That's all.

Posted by: Cairn at May 4, 2007 06:14 AM

Spot on, Lilly. And you're right too Philip, it's pretty preposterous not to extend this warning to all ages. The so-called protective effect in the elderly is based on flawed data. Who ever heard of a side effect in any other drug that's age related? It's stupid.

Posted by: Sara at May 4, 2007 07:03 AM

I'd like to know why they didn't test more extensively before giving these meds to people. When my shrink started me out on antidepressants 15 years ago, I started with Zoloft, then Paxil, then Wellbutrin, then back to Zoloft. I was moody, foggy, and befuddled, and STILL miserable. All gave me side-effects. (The sexual side-effects were really irritating, or was I irritated because they made me grumpy, too? :p) Zoloft made me suicidal, especially when I had had enough and went cold turkey. I figured I was moody before, I'd just be moody again. Boy, that was a rough month.

A few years later, a doctor was shocked to find out I went cold turkey. Seemed HE knew about Zoloft's side-effects even if the public didn't. He told me that 5% of the population that stops taking Zoloft becomes suicidal. Sheesh. It would have been nice to know that before I even started taking them.

I'm better off now using mind over mood to conquer my Depression.

Great blog. Thanks.

Douglas Cootey
The Splintered Mind

Posted by: D Cootey at May 9, 2007 04:51 AM

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