February 16, 2007The Zyprexa Chronicles: Time For The Media And Others To Do Their JobsIt probably comes as no comfort to Eli Lilly that yesterday Slate.com wrote up one of the Zyprexa documents, apparently downloaded from this here website. Go read their nice piece here. Many thanks to Slate. This makes me wonder where the hell is the rest of the media on the Zyprexa story. The Times gets the documents first and busts out some great stories in December, does some folos and the rest of the major national media goes slinking away like babies because they were "beaten" on the story. Big deal. Only the Times of London has gotten on them since, although everyone has taken a little run at the story of the documents, the court ruling and Alex Berenson. "60 Minutes" was supposedly poking around the story as well, but I've heard nothing more about them. I know NPR has the documents, so does the Wall Street Journal. I bet that the Washington Post and Los Angeles Times have them as well. Silence has been the result. Um, I think there are some editors, and maybe some reporters, who need to understand that the story here is bigger than they think. Or have they all forgotten about the many revelations around Prozac in the 90s, Paxil in the 90s and the 00s, and now Zyprexa? Are there some dots they are incapable of connecting? I'm a nobody but let me try to help. Zyprexa is but one of class of drugs called atypical antipsychotics. The others are clozaril (which has killed people), Risperdal, Seroquel, Abilify and Geodon. (Serdolect never made it to market in this country because it ran into too many problems in the UK.) You know the news around Zyprexa. Risperdal's maker, Johnson & Johnson/Janssen, is currently tied up in court in Texas in a lawsuit brought by the state for allegations around the company using undo influence and potentially illegal schemes to get the state to use the drug. AstraZeneca, Seroquel's maker, is facing 10,000 lawsuits related to allegations of product liability. Bristol Myers-Squibb, Abilify's maker, recently settled a huge case with the feds for reasons that I still cannot fully figure out (gee, bet those documents are sealed too!). So this is a class of drugs with big problems and Big Pharma has behaved incredibly sleazily in promoting their use. BMS had ads for Abilify on phone booths in Seattle and Philadelphia recently--have you guys ever seen such a blatant attempt to mainstream such an obscure product? I think everyone has a clear idea of how Lilly handled Zyprexa. And guess what guys? These drugs don't work too well either. There are at least two major long-term, independent studies that now establish this. Yet these same drugs are now being given to millions of children and teens, and many millions of more adults--and not just for schizophrenia, for which they were designed, but for very mild cases of bipolar disorder (as a sleeping aid no less), for combative kids, for depression, for anxiety and so on. I have previously detailed just how aggressively AZ is trialing Seroquel for everything under the sun, including among FOUR-YEAR-OLDS for this trumped-up bipolar disorder in kiddos. If you guys in the media don't smell a story, then you need a fresh cup of coffee. I'll buy. In addition, I am confused as to why the American Psychiatric Association, the American Medical Association, the American Psychological Association and their fellow organizations in the UK, Europe and Australia haven't issued even the most tepid of statements on the matter. What part of Hippocratic Oath and social responsibility don't you people get? If the APA doesn't take up Zyprexa and the atypicals at its national convention in San Diego in June, then it is asleep at the switch. I am just as frustrated with many of the so-called advocacy groups for the mentally ill. DBSA, NAMI, CABF. You guys have said nothing. Or are you busy cashing checks from Lilly? The only good actor among the mainline advocacy groups has been MHA (NMHA) which, last week, signed on as part of the legal challenge to the documents remaining sealed. Good for you guys. But you have still taken no public position on this matter. It is time as well for the feds to step up to the plate. Earlier this week, David Graham, who seems to be the only brave person at the FDA, testified before a Congressional subcommittee on the fact that the FDA knew full well the problems with Zyprexa. It is time for Congress to press harder on this matter. It is time for the FDA to get off its butt and investigate Zyprexa, and itself while its having fun. The FTC should be looking into this matter as well, and so should the SEC. It's time for everyone out there to wake up. And do their jobs. Posted by Philip Dawdy at February 16, 2007 12:01 AM
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The problem seems to me to be that pharma companie$ adverti$e a lot and have long memorie$. I would bet dollars to donuts that the more money an entity receives from big pharma, the less likely it is to criticize big pharma. Posted by: lurker at February 16, 2007 12:49 AMIn addition, I am confused as to why the American Psychiatric Association, the American Medical Association, the American Psychological Association and their fellow organizations in the UK, Europe and Australia haven't issued even the most tepid of statements on the matter. What part of Hippocratic Oath and social responsibility don't you people get? You don't think (possibly) that there is an element of "guilt by association" at work here? No, probably not . . . those god-like physicians who comprise these organizations know little about guilt . . . only about "liability." Wouldn't an admission that they mis-prescribed be an admission of culpability and open them up to lawsuits? Doctors UNDERSTAND lawsuits and will deny responsibility as long as they possibly can--to hell with Hippocrates! If you're referring to the same American Psychological Association that has as its top goal to get psychologists "prescription privileges," meaning to allow psychologists to prescribe psych meds, then don't expect them to take a stand. If you look at APA's lack of stand-taking regarding psychologists' roles in military interrogations, then you can also guess that APA is not a group that challenges authority despite being labeled by some as a bunch of hippie liberals. There is no question anyone who prescribed Zyprexa will use "I didn't know the truth either" as a way to remain out of court in this matter. The truth is here now though. It IS time for all involved to step-up to the plate. The reckless prescribing of antipsychotics for use such as insomnia, anxiety,etc. and especially in kids under 18 is the first place to begin to STOP this madness. I don't understand how any doctor can look the other way when reading the already existing prescibing information on (for instance Zyprexa, etc)these meds and not shake in their boots wondering if their patient will remain alive as a result of use.(and especially in kids under 18). To use an antipsychotic, such as these (Zyprexa,Clozaril,Seroquel,etc.)without considering possible outcomes in my opinion: is reckless endangerment of lives. The general public MUST ask for this information at minimum, at the pharmacy. It's even online. There are no secrets in the fine print there. Reading the fine print alone scares me to death that myself or loved one(s)don't die as a result of ingesting medications like these in the pursuit of a quality life.
This is one of the biggest 'connect the dots' ever; and once the pattern is shown, it will be clear the industry is a fully-loaded hierarchy of deceipt. Posted by: Stephany at February 16, 2007 09:04 AM.."What part of Hippocratic Oath and social responsibility don't you people get?" I used that phrase in various speeches to several big-wig psychiatrists when advocating for my family member. Reminding psychiatrists (or any doctor) of the "Oath" and "First do no harm" can be a pretty interesting discussion to say the least. I wasted no time reminding docs they have a responsibility, to 'do no harm'. ( I didn't receive a flower bouquet of thanks for that either.(sarcasm).) Patients, consumers, advocates: speak up. It's YOUR responsibility also. The system can't and won't change without YOUR hard work. I’ve been wrestling with why this isn’t a bigger story for five years, ever since I got into this business with the psych drug induced death of my daughter. To add insult to injury where is Alex Berenson now? Off writing a novel. Please. I sure hope the pharmaceutical industry is at least a player in his novel, another King of Torts or Constant Gardener. Why isn’t he writing this all up in more detail? And writing non-fiction instead of fiction? Believe me the truth is plenty thrilling enough. The fact is journalists have a very short attention span it seems (present company excepted of course). And worse than that the public isn’t really reading the papers the way they should either. It seems the most avid readers of all these articles are the people who already understand what’s going on. The sad fact is the scope of this problem embraces something much greater than poor treatment paradigms. Until patients stop wanting diagnoses and treatment with pills this isn’t going to be a very news-grabbing story. We are really talking about a cultural problem here. Also this really isn’t just about pills being approved legitimately and then dangers being discovered later. The approval process itself is rife with corruption. Please read Mad in America to learn the story of how atypicals were approved. The clinical trials were a farce. Severely mentally ill “treated” patients were taken off meds abruptly right before the trials, endured a short and brutal withdrawal period, and then some were put on placebo and some were put back on the new drugs. Some of the people who conducted these trials are now in jail! No wonder the patients who were on the drugs did better; the other group was still in the throes of a brutal withdrawal. Is this any way to approve a drug? Furthermore the trials were only a few weeks long generally as if this is going to prove anything when as we all know people are put on these drugs for the duration. David Healy has called Zyprexa the most deadly drug that’s ever been approved (sorry don’t have a specific reference handy but something like that anyway). Meanwhile the murder and mayhem caused by the drugs is increasing exponentially. I helped create the site www.ssristories.com. It’s a layman’s effort to do a little epidemiological study of what’s going on in clinical practice with people taking antidepressants and it’s a horrifying picture. It doesn’t prove a lot but it is certainly some kind of signal of something dangerously amiss. And even this list of stories doesn’t really attract a lot of interest. You’d think in a way someone would jump on it but nope – met with sighs and groans. Until we move away from the allopathic model and recognize that even mania and psychosis might be better treated with a bare minimum of drugs this story is not going to have legs. I wrote a review of A Beautiful Mind that’s on Amazon under “Justiceseeker”. The author of that book was one smart lady but she missed the message. Everyone was totally befuddled about how John Nash could have gotten better without more treatment and came up with all sorts of fabrications about why his case was so unique instead of grasping the main point that it was precisely because he had so little treatment that he got better. Even he didn’t get it as he supports the aggressive treatment his poor son is now enduring. The film of the book went so far as to misrepresent the amount of treatment he did have so as not to scare off “treated” people in the audience who might be tempted to stop their meds if they knew the truth. But you know what -- despite hitting our heads against a brick wall we need to keep at it because some kind of tipping point is fast approaching and we have to make it happen. And lives are at stake. Sara, First, thank you for sharing your wisdom based on grief of losing your daughter. There are no words for such a loss. Several key points you make in your post that are so important: 2."avid readers ...already ..understand (the issue). Your voice on this blog, has been very informative, and I commend you for speaking out here. Thank you for sharing. Berenson may have been "encouraged" to go fly a kite I mean go write a book. Judge Weinstein wrote that his conduct was reprehensible. Posted by: lurker at February 16, 2007 07:37 PMThanks for the support Stephany. Just wanted to clarify that Berenson is taking a leave to write his novel. I kind of assume this was planned before the Zyprexa story broke but don't know. It just strikes me as a shame that he's not writing a book on some of the stuff he's learned through his reporting, which I have always considered excellent, instead of a novel. I didn't mean to imply that his articles should have been more detailed. This will not be his first novel so I appreciate he likes writing fiction and probably has a talent for it. I just wish someone of his caliber would turn their writing skills to this topic in book form (but then again it wouldn't have the potential to be a blockbuster perhaps the way a novel does). Posted by: Sara at February 17, 2007 08:22 AMAnd it gives the appearance that journalists--just like Big Pharma--are always chasing the blockbuster. Posted by: Melody at February 17, 2007 11:54 AM |
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