January 19, 2007

Dept. Of Meaningless Research: Smoking Tied To Suicide In Bipolar Disorder

Regardless of your thoughts on smoking, here's a study that claims it can connect smoking with a heightened risk of suicide in patients with bipolar disorder. Anyone who knows much about suicide and suicidality knows that there are a constellation of factors at play in most suicides. Sigh. I am not even going to spend time bashing this study, except to note: the study was done by Harvard researchers; I cannot wait to see to what end the anti-smoking crowd puts this study; it reminds me of a conversation I had with a Drug Enforcement Agency agent last summer. I was reporting a story on medical marijuana and, as I always do, called the other side for a comment. Our conversation went kind of like this towards the end:

DEA Agent: "Drugs are bad. Don't do drugs."

Me: "How is medical marijuana bad?"

DEA Agent: "Marijuana causes schizophrenia."

Me: "I've read those studies and don't think it's a very strong correlation."

DEA Agent: "Well, that's what they say."

Me: "Can I tell you something?"

DEA Agent: "Sure."

Me: "I should be the most schizophrenic guy in America."

Sometimes I cannot help myself.

Posted by Philip Dawdy at January 19, 2007 12:06 AM
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Comments

Ludicrous.

While smoking tobacco is not good for you (inaling smoke, duh!), nicotine has proven to be a positive antagonist against acetylcholine, serotonin, noradreline and to a lesser extent dopamine receptors.

Subseqently the nicotine compound is being researched as antidepressant, analgesic and antiflammatory. I'm sure if they hit the market they won't be "addictive" ;)

Just do a pubmed search on nicotine and antidepressant. Interesting stuff. My favorite is the one that suggests venaflaxine and nicotine could be a viable (read commercial) therapeutic approach to smoking cessation.

Posted by: zipzip at January 19, 2007 08:22 AM

Doesn't everyone know that smoking causes cancer(and many other health problems? YES?
To smoke therefore is to want to get cancer, which is suicidal in itself.
How stupid are these researchers?

Posted by: Mark at January 19, 2007 10:57 AM

Haha...I wish I could have witnessed that conversation with said agent! Priceless.

And hold on: they are basing this on only 155 subjects who had a history of daily smoking. This is a good example of tooting your own horn before you've made good scientific research with it. How about we get some larger research groups?

...it's a silly study anyway...but if you are going to persist, do it right.

Posted by: Priscilla at January 19, 2007 06:01 PM

Ever since schizophrenia was linked to delayed PTSD back in the late 60's, from a childhood trauma sometimes being from circumcision, proponents of circumcision are desparately trying to blaim schizophrenia on every thing else. Marijuana might be a trigger for a schizophrenic episode, but not the cause. Genes might be involved, as the tradition of circumcising runs in the family as do genes, but now it looks like it's mothers X chromosomes as it often runs with mother to daughter and mother to son. The way the mother gets it is usually from some type of infant rape or sexual abuse,infections and toxins, and surgeries. Boys who recieve these types of neonatal traumatic shocks are prone to the same brain chemistry malfunction after puberty. Disruptions in the nursing cycle at this stage of developement confounds the negative side effects further leading to paranoid delussional schizophrenia with audio and visual hallucinations caused from the lack of certain milk fat digesting enzimes that were suposed to be introduced from first milk. Our reptilian part of our brain handle reproduction/sexual affection and dopamine production. The male and female prepucial frenular delta nerves trigger these regions of the brain and severing them causes the schism that leads to schizophrenia, sexual dysfunctions, and suicidal depressions. Support MGMbill.com

Posted by: FredR at January 21, 2007 06:51 AM

Is there any forum or interest in one of the most researched risk factors for schizophrenia? T

If so read on

Rasmussen F. Related Articles, Links
Paternal age, size at birth, and size in young adulthood - risk factors for schizophrenia.


In fully adjusted analyses, the risk of schizophrenia was 4.62 (95% confidence interval : 2.28; 9.36) times higher in subjects whose fathers were >/=50 years old and at time of conception than in subjects whose fathers were 21-24 years old. Growth and development in fetal life and childhood are influencing the risk of schizophrenia in adulthood, but the underlying causal pathways are still unknown. De novo mutations in the germ cells of older fathers may play a causal role in the etiology of some cases of schizophrenia.

: Eur Psychiatry. 2006 Dec 1; [Epub ahead of print] Links
Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring.Wohl M, Gorwood P.
INSERM U675, 16 rue Henri Huchard 75018 Paris, France; AP-HP (Paris VII), C.H.U Louis Mourier, Service de psychiatrie du Professeur Ades, 178 rue des Renouillers, 92701 Colombes Cedex, France.

BACKGROUND: A link between older age of fatherhood and an increased risk of schizophrenia was detected in 1958. Since then, 10 studies attempted to replicate this result with different methods, on samples with different origins, using different age classes. Defining a cut-off at which the risk is significantly increased in the offspring could have an important impact on public health

http://press.psprings.co.uk/jech/october/851_ch45179.pdf
http://www.intelihealth.com/IH/ihtIH/WSIHW000/35320/63153/491833.html?d=dmtHMSContent
http://list.web.net/archives/mnchp-l/2004-April/000508.html
http://www.sciencedaily.com/releases/2002/11/021126201311.htm

Schizophrenia is too lucrative for the research on the way to prevent it in non-familial cases to be publicized.

Posted by: Leslie Feldman at January 23, 2007 08:25 PM

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