May 03, 2006No Silver Bullets, No Heroes Or Fuck ZyprexaAs I mentioned two days ago, a new study came out examining whether Zyprexa could be used to prevent, or delay, the onset of psychosis in people--most of them teens--assumed to be at risk of developing schizophrenia. I got a full copy of the paper yesterday. The results were not good both for Eli Lilly, Zyprexa's maker, and for the prevention paradigm of the public health model--at least in how it's applied in mental health settings. In the study, 55 percent of the patients taking Zyprexa dropped out of the study due to side effect of the drug. Consistent with many other studies of the antipsychotic were patients who gained weight rapidly and who had elevated heart rates. The study did not examine patient blood sugar levels--utterly asinine given Zyprexa's well-known ability to kick start diabetes in patients. Two dozen patients have reportedly died from taking Zyprexa. So why the researchers didn't examine that question as well is hard to image. Last summer, Eli Lilly settled a class-action suit brought by patients and families of dead patients for $750 million (the pay out to plaintiffs will be $690 million) rather than have a multi-billion dollar verdict go against it in court. That over half of the study subjects bailed 'cuz they couldn't handle taking the med is indictment aplenty. In the recent CATIE study, 64 percent of the patients discontinued Zyprexa for similar reasons. Meds ain't worth a shit if they ruin your life. But that was just the beginning of the bad news for Eli Lilly. All of the patients taking Zyprexa who later developed did psychosis did so within 4 weeks of beginning treatment with the drug. I am not inferring that the drug caused psychosis. But it's a lame bit of chemicals that's advertised for managing psychosis in schizophrenics and bipolars (and is one of the world's top-selling drugs) and cannot get the job done out of the chute. Lamery, thy name is Zyprexa. Study authors concluded that the drug didn't prevent psychosis, but perhaps only delayed its onset. But they couldn't--or wouldn't--say for sure whether that alleged delaying (a few months, tops) was the result of some patients taking the drug and getting a benefit from it. But, then, only 16 percent of the patients who took the drug received a benefit at all. That's just way too small a number to be enthusiastic about using Zyprexa for people believed to be at-risk of developing psychosis--schizophrenia, in other words. But, then, Eli Lilly paid for the study, so what do you expect the docs to say? You know what's coming. They called for further studies to bear out their findings. Why do these guys always act like the jury is still out on both a drug and class of medication that have been widely-discredited? House payments. Another point: for the last 20 years or so, researchers and public health officials (and pharma companies, of course) have been searching for the silver bullet med. The molecule that will turn them into heroes for prescribing it to patients. In the case of the public health crowd, they'd like to be declared heroes and redeemers for then forcing the silver bullet down every person's throat should they act a little sketchy. Bad news, guys. It's not going to happen here. Not with Zyprexa and not with any of the other atypical antipsychotics. Not for bipolars, not for schizophrenics. This ain't the world of infection and Zyprexa is no penicillin. So, in other words, fuck Zyprexa. There were some other key studies in the same issue of AJP. I'll come to them in he next few days. Posted by Philip Dawdy at May 3, 2006 12:01 AM
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I don't know Philip. Zyprexa may have been preventing my daughter's stuff, by accident(?)I am so now not knowing what to think. Posted by: Stephany at May 3, 2006 09:55 AM"Doctors pour drugs of which they know little, to cure diseases of which they know less, into human beings of whom they know nothing."~ Voltaire Posted by: Stephany at May 3, 2006 12:34 PMExactly 'fuck zyprexa' i took it from 1996-2000 and now i have type 2 diabetes.-Daniel Haszard Posted by: Daniel Haszard at May 4, 2006 05:36 AMA few more thoughts on this, due to the 6 year taking of Zyprexa by my daughter from age 11>17 1/2, it gives idea to many things: did this drug in a strange way keep at bay the pscyhotic break that she is having now at age 18? was it a preventative to the Prodomal , that calm before the storm into Schizophrenia? Did it stop psychosis? No. Was her life perfect on it? No. She had weight gain, her eyes bothered her, and she herself hated being on it. Once off, and at the 'typical' emergent age of schizophrenia, now docs wonder, was something else emerging anyway? Did she need the ZYprexa all of those years? Did her brain grow with it and become dependent on it? Biggest question of all: Some side effects straight off of zyprexa prescribing sheet that can indeed cause someone to say, that after 4 weeks the med 'made them psychotic'...I believe in psychiatric side effects, doctors won't even hear that conversation, and reading these side effects herself, is what caused my brilliant daughter, to say her phrase of the day: "Is this me or the meds? Hi Stephany, I feel like I could really relate to your daughter. We've probably both been through very similar things. From having side effects, to being at Children's... we probably have a lot in common. How is she doing nowadays? Is she in school? What are her interests? I really hope that she's doing well... My thoughts are with her! Posted by: Gwen at July 9, 2006 05:07 PMHi Gwen, My daughter is leaving a hospital for a step towards home next week. That's awesome, Stephany!!! I'm so happy for her. Tell her she always has a friend in me. Gwen Posted by: Gwen at July 11, 2006 12:33 PMThanks Gwen, I know one thing, you are an inspiration to many! Thanks Posted by: Stephany at July 12, 2006 08:05 AMYeah, I got off Zyprexa too, First I was 302ed elegaly by my parents Iam 23 years old and was entered agaist my own will on 12/9/06 at Grand Veiw Hospital. I think my just made my dad fell like a tough guy in front of my mom.I had all of the same symtoms,and belive me it was hell,I think the Dr.Santina gave me 10mg just becuse I was a big guy 6'1"193lbs when I started.He had the court assign me more time just to cover his fat ass leagaly.The Zyprexa made me so weak my home doctor gave me Liposril or somethig.I had a job in Masonary as a Laborer Since I was seventeen.12/9/06 was my last day of work. It is currently 5/20/07 I dont have Liposril any more,I was tested for diabetes, came out negative, I slowy have been getting my energy back very slowly, it hurts to to exersize now, and that hurts me because Iam a very athletic person, that is before Zyprexa. Iam still living at home with my parents me and my dad don't talk much anymore, but he is currently paying for the 2006 Dakota I bought when I was working. Iam going to see a Rehmotologist about my pain on 6/24/07 I hope it will go away so far the Er at the same hospital gave me three inflamatoin shoots.My skin color got better after I ate some shellfish,Lobster turst me It went from red back to fair skinned-afican american again. I hope the Rehmotologist will help me with my pain I have back pian, sholder pain, neck pain and I have headaces when I masterbate. The Doctor's in the Er told me it was because of my enzyme count I never expericed pain like this before. The weight gain I now weigh 208lbs.Now I have an ugly beer gut without drinking. Fuck Zyprexa My old man better wacth it when he's old and feabil he might be on and off Zyprexa. Posted by: Chris Goolsby at March 20, 2007 09:29 PMMy thinking outloud here regarding Zyprexa being a possible prevention in a Prodromal period before Schizophrenia is a thought to continue, worthy of discussion.There are some theories out there that hold the Prodrome period important to make note of re: the complexity of diagnosing schizophrenia. I wrote the original posts 3 weeks before an MRI of her brain was completed with results showing an organic brain malformation. She was also taken off of Zyprexa forever; and placed on Clozaril June 2006. Posted by: Stephany at March 21, 2007 08:39 AM |
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