May 03, 2006

No Silver Bullets, No Heroes Or Fuck Zyprexa

As I mentioned two days ago, a new study came out examining whether Zyprexa could be used to prevent, or delay, the onset of psychosis in people--most of them teens--assumed to be at risk of developing schizophrenia. I got a full copy of the paper yesterday. The results were not good both for Eli Lilly, Zyprexa's maker, and for the prevention paradigm of the public health model--at least in how it's applied in mental health settings.

In the study, 55 percent of the patients taking Zyprexa dropped out of the study due to side effect of the drug. Consistent with many other studies of the antipsychotic were patients who gained weight rapidly and who had elevated heart rates. The study did not examine patient blood sugar levels--utterly asinine given Zyprexa's well-known ability to kick start diabetes in patients. Two dozen patients have reportedly died from taking Zyprexa. So why the researchers didn't examine that question as well is hard to image. Last summer, Eli Lilly settled a class-action suit brought by patients and families of dead patients for $750 million (the pay out to plaintiffs will be $690 million) rather than have a multi-billion dollar verdict go against it in court.

That over half of the study subjects bailed 'cuz they couldn't handle taking the med is indictment aplenty. In the recent CATIE study, 64 percent of the patients discontinued Zyprexa for similar reasons. Meds ain't worth a shit if they ruin your life.

But that was just the beginning of the bad news for Eli Lilly. All of the patients taking Zyprexa who later developed did psychosis did so within 4 weeks of beginning treatment with the drug. I am not inferring that the drug caused psychosis. But it's a lame bit of chemicals that's advertised for managing psychosis in schizophrenics and bipolars (and is one of the world's top-selling drugs) and cannot get the job done out of the chute. Lamery, thy name is Zyprexa.

Study authors concluded that the drug didn't prevent psychosis, but perhaps only delayed its onset. But they couldn't--or wouldn't--say for sure whether that alleged delaying (a few months, tops) was the result of some patients taking the drug and getting a benefit from it. But, then, only 16 percent of the patients who took the drug received a benefit at all. That's just way too small a number to be enthusiastic about using Zyprexa for people believed to be at-risk of developing psychosis--schizophrenia, in other words.

But, then, Eli Lilly paid for the study, so what do you expect the docs to say? You know what's coming. They called for further studies to bear out their findings. Why do these guys always act like the jury is still out on both a drug and class of medication that have been widely-discredited? House payments.

Another point: for the last 20 years or so, researchers and public health officials (and pharma companies, of course) have been searching for the silver bullet med. The molecule that will turn them into heroes for prescribing it to patients. In the case of the public health crowd, they'd like to be declared heroes and redeemers for then forcing the silver bullet down every person's throat should they act a little sketchy.

Bad news, guys. It's not going to happen here. Not with Zyprexa and not with any of the other atypical antipsychotics. Not for bipolars, not for schizophrenics. This ain't the world of infection and Zyprexa is no penicillin.

So, in other words, fuck Zyprexa.

There were some other key studies in the same issue of AJP. I'll come to them in he next few days.

Posted by Philip Dawdy at May 3, 2006 12:01 AM
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Comments

I don't know Philip. Zyprexa may have been preventing my daughter's stuff, by accident(?)I am so now not knowing what to think.

Posted by: Stephany at May 3, 2006 09:55 AM

"Doctors pour drugs of which they know little, to cure diseases of which they know less, into human beings of whom they know nothing."~ Voltaire

Posted by: Stephany at May 3, 2006 12:34 PM

Exactly 'fuck zyprexa' i took it from 1996-2000 and now i have type 2 diabetes.-Daniel Haszard

Posted by: Daniel Haszard at May 4, 2006 05:36 AM

A few more thoughts on this, due to the 6 year taking of Zyprexa by my daughter from age 11>17 1/2, it gives idea to many things: did this drug in a strange way keep at bay the pscyhotic break that she is having now at age 18? was it a preventative to the Prodomal , that calm before the storm into Schizophrenia? Did it stop psychosis? No. Was her life perfect on it? No. She had weight gain, her eyes bothered her, and she herself hated being on it. Once off, and at the 'typical' emergent age of schizophrenia, now docs wonder, was something else emerging anyway? Did she need the ZYprexa all of those years? Did her brain grow with it and become dependent on it? Biggest question of all:
She was not placed on this med for psyhosis prevention. So would we have given it to her, if a doctor in 1999 said he thinks it could prevent something down the road? NO. This is what no one knows. It is still a guessing game, and if I remember right a side effect of Zyprexa is psychosis, right down to schizophrenic reaction. I truly feel no study can assure anyone of what to take or do re:meds. It would have to be something like a miracle to get me thinking that way. They would flat out have to prove "cure" to me to get on a med that "could help" something so absract as psychosis and delusions. Now that she is fully actively psychotic, none of the antipsychotics have been able to kick it out in 8 months. So, was she preventing, slowing up this big abyss by being on ZyPrexa for 6 years as a young child? who the hell knows. Let's say they did brain imaging extensively when she was 11, and concluded a low dose maintenance of 2.5>5mg of Zyprexa could prevent her or delaying full blown schizophrenia, when she was 18. Would I have placed her on that then? I seriously doubt it. Look at the side effects. Side effects that were before the whole diabetes thing. Another way to look at her situation: what if she remained on Zyprexa? would she have not missed her Senior year this year, turned 18 in December at home, and not a hospital? that other side of the crappy coin, the forever what if's. Would this have emerged anyway, no matter what she was on? Conclusion after 6 years of her personal study: life wasnt perfect.She felt crappy most of the time, escalating into misery, on drugs. Off drugs it's like she fell off a cliff. So miserable existance dominated by medication dosing , and guessing, and ending up asking as she grew older, "is this me or the meds?" I think she askd the smartest question of all. Given a choice to go off of them, she took it.That says a lot too.

Posted by: Stephany at May 4, 2006 06:48 AM

Some side effects straight off of zyprexa prescribing sheet that can indeed cause someone to say, that after 4 weeks the med 'made them psychotic'...I believe in psychiatric side effects, doctors won't even hear that conversation, and reading these side effects herself, is what caused my brilliant daughter, to say her phrase of the day: "Is this me or the meds?
These are listed in that 2% of people having these reactions: who says you can't fall into that category? and who reports these events? not many, because their docs just give em more meds saying that they are what they are....She experienced all of these on ZYprexa.Then experienced them off of zyprexa.
1.Agitation
2.Anxiety
3.Confusion\
4.Depression
5.Hallucinations
6.Hostility
7.Nervousness
8.Paranoid reaction
9.Personality disorder
10.Thinking abnormal
Listed under FREQUENT side effects: Delusions,emotional lability,dilirium,manic reaction,OCD symtoms,among others....Those are the very things she was battling over the years on the drug, besides weight gain, back pain, sweating, and tremors, sleeping and needing to go to school late due to morning fatigue, all of these things frankly, as a 17 yr old, reading them for herself, online in a library, spurred her to wonder if she was a medication reaction. This was a very difficult time for her, and she cried at the thought that she was on medication making her act like she didnt feel inside her heart. So she herself took the chance, that med free choice offered up to the table, and as anyone can imagine, to have it end up worse that when she was on the med is even more heartbreaking to her,and for her. Take this thought to another level, was she then suffering from Neuroleptic Drug Withdrawal syndrome?once zyprexa was gone? what if she could have held out for a few months, like when she came off of Zoloft? would she be fine now? had the med kept what the inevitable at bay for a while? This is what is wrong with all of this. The vicious cycle, and I am sure more people fall into this category than we would like to think. It is way to easy for docs to say, well this was going to happen anyway, look at her age. I wonder how many people are drugged up and locked up, needlessly on a medication reactions in the psychiatric category, being medicated for side effects, and ending up shuffling the halls forever. Mental health crisis, and the sad thing is, not many people get to walk the halls of psychiatric hospitals to see what could be the result of medication reactions. I have seen it. If these meds truly helped, why is there a bed shortage? there shouldn't be need for hospital beds if we had meds that truly worked, hospital beds would be empty. They are not empty folks, they are full, the bed lists are long, and there aren't enough beds for all, you pretty much have to become gravely disabled, or violent to get one of those beds. The packed psychiatric hospitals are not full of lost causes, they are full of patients, human beings, who need us to get more research, and to get louder when we complain about lack of mental health coverage, and care. Patients may not walk around in chains any longer, but they sure are sometimes in locked environments that appear like jail. Dignity lacks. They look out of windows with grates on them. The cold tile floors, the plastic mattresses, maybe they are needed, but the places sure as hell don't feel like home. The worst part? Who knows where these hospitals are? Does anyone ever go volunteer at them? How much does society really not want to talk about this? It is pretty obvious. Children's in Seattle, was the most plush of all units we were part of, and look at the fundraising background there.The fundraising efforts need to be promoted in ugly, run down buildings too Melinda Gates. I would like a Melinda Gates building for psychiatric care only please. More than one. Get off your humble pie speech at Children's ribbon cutting and get public about what my young daughter has seen.No brown paper bag lunches served at Children's.I would also like to see Children's expand their unit, on that property, a stand alone psychiatric hospital.Most of the patients in the Children's unit were eating disorder patients, and my daughter was psychiatric, psychotic, and was expected to be part of the famous 'milieu'. My daughter, having true psychiatric issues was rare in the Children's unit.Why was that? The more she 'acted up' she was locked in her room. How else to keep a delusional, psychotic person in a psych unit housing eating disorder patients out of their way so they could do their activities? At one point, my daughter was also denied visiting with her favorite therapy dog, because she was psychotic and delusional.She met that dog at another psych hospital, and was in the same frame of mind. Being sick, just locked her down harder.I feared her going to Western, but once she was there, the freedom to run the halls was something that surprised us all, she was happier there, and she wasn't locked down.She went straight from a locked bedroom for weeks from Children's to an open ward free to walk, at Western ,and she was never locked inside her room. Lots to think about isn't there?

Posted by: Stephany at May 4, 2006 07:46 AM


I took zyprexa which was ineffective for my condition and gave me diabetes.

{Only 9 percent of adult Americans think the pharmaceutical industry can be trusted right around the same rating as big tobacco}

Zyprexa, which is used for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, accounted for 32% of Eli Lilly's $14.6 billion revenue last year.

Zyprexa is the product name for Olanzapine,it is Lilly's top selling drug.It was approved by the FDA in 1996 ,an 'atypical' antipsychotic a newer class of drugs without the motor side effects of the older Thorazine.Zyprexa has been linked to causing diabetes and pancreatitis.

Did you know that Lilly made nearly $3 billion last year on diabetic meds, Actos,Humulin and Byetta?
Yes! They sell a drug that causes diabetes and then turn a profit on the drugs that treat the condition that they caused in the first place!

I was prescribed Zyprexa from 1996 until 2000.
In early 2000 i was shocked to have an A1C test result of 13.9 (normal is 4-6) I have no history of diabetes in my family.
----
Daniel Haszard http://www.zyprexa-victims.com

Posted by: Daniel Haszard at July 7, 2006 08:07 AM

Hi Stephany,

I feel like I could really relate to your daughter. We've probably both been through very similar things. From having side effects, to being at Children's... we probably have a lot in common. How is she doing nowadays? Is she in school? What are her interests? I really hope that she's doing well... My thoughts are with her!

Posted by: Gwen at July 9, 2006 05:07 PM

Hi Gwen,
That is really nice of you to ask about her. She has been through a lot, and has missed much of high school being in hospitals. She is doing better, most recently, the last few weeks. She is still in a hospital. She loves to ride horses, paint, read and she volunteered a lot.
Thanks for sending her good thoughts, that is super kind of you.
I hope you continue to do well:) You are an inspiration.
Stephany

Posted by: Stephany at July 10, 2006 01:23 AM

My daughter is leaving a hospital for a step towards home next week.
:)

Posted by: Stephany at July 10, 2006 07:31 PM

That's awesome, Stephany!!! I'm so happy for her. Tell her she always has a friend in me.

Gwen

Posted by: Gwen at July 11, 2006 12:33 PM

Thanks Gwen, I know one thing, you are an inspiration to many! Thanks

Posted by: Stephany at July 12, 2006 08:05 AM

Yeah, I got off Zyprexa too, First I was 302ed elegaly by my parents Iam 23 years old and was entered agaist my own will on 12/9/06 at Grand Veiw Hospital. I think my just made my dad fell like a tough guy in front of my mom.I had all of the same symtoms,and belive me it was hell,I think the Dr.Santina gave me 10mg just becuse I was a big guy 6'1"193lbs when I started.He had the court assign me more time just to cover his fat ass leagaly.The Zyprexa made me so weak my home doctor gave me Liposril or somethig.I had a job in Masonary as a Laborer Since I was seventeen.12/9/06 was my last day of work. It is currently 5/20/07 I dont have Liposril any more,I was tested for diabetes, came out negative, I slowy have been getting my energy back very slowly, it hurts to to exersize now, and that hurts me because Iam a very athletic person, that is before Zyprexa. Iam still living at home with my parents me and my dad don't talk much anymore, but he is currently paying for the 2006 Dakota I bought when I was working. Iam going to see a Rehmotologist about my pain on 6/24/07 I hope it will go away so far the Er at the same hospital gave me three inflamatoin shoots.My skin color got better after I ate some shellfish,Lobster turst me It went from red back to fair skinned-afican american again. I hope the Rehmotologist will help me with my pain I have back pian, sholder pain, neck pain and I have headaces when I masterbate. The Doctor's in the Er told me it was because of my enzyme count I never expericed pain like this before. The weight gain I now weigh 208lbs.Now I have an ugly beer gut without drinking. Fuck Zyprexa My old man better wacth it when he's old and feabil he might be on and off Zyprexa.

Posted by: Chris Goolsby at March 20, 2007 09:29 PM

My thinking outloud here regarding Zyprexa being a possible prevention in a Prodromal period before Schizophrenia is a thought to continue, worthy of discussion.There are some theories out there that hold the Prodrome period important to make note of re: the complexity of diagnosing schizophrenia.

I wrote the original posts 3 weeks before an MRI of her brain was completed with results showing an organic brain malformation.

She was also taken off of Zyprexa forever; and placed on Clozaril June 2006.

Posted by: Stephany at March 21, 2007 08:39 AM

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